普萘洛尔辅助治疗肝硬化上消化道出血的效果及对血流动力学的影响

Effects of Propranolol on the treatment of upper gastrointestinal bleeding in cirrhosis and its effect on hemodynamics

目的探讨普萘洛尔辅助治疗肝硬化上消化道出血的效果及对血流动力学的影响。方法回顾性分析本院2016年6月～2017年12月收治的75例肝硬化上消化道出血患者,根据临床用药方式分为对照组(35例)和研究组(40例)。对照组采取奥曲肽治疗,研究组采取奥曲肽联合普萘洛尔治疗。比较两组的临床治疗效果、不良反应发生率及对血流动力学的影响。结果研究组治疗总有效率(92.50%)显著高于对照组的68.57%,差异有统计学意义(P<0.05);治疗后,研究组的中心静脉压、平均动脉压、门静脉血流量、脾静脉血流量等指标均显著优于对照组,差异均有统计学意义(P<0.05);研究组不良反应总发生率为7.50%,显著低于对照组的22.86%,差异有统计学意义(P<0.05)。结论采用奥曲肽联合普萘洛尔治疗肝硬化上消化道出血临床效果显著,且安全性较高,有积极的临床价值。

Objective To explore the effect of Propranolol on the treatment of upper gastrointestinal hemorrhage and its effect on hemodynamics.Methods Retrospective analysis of 75 patients with upper gastrointestinal hemorrhage in our hospital from June2016to December2017.The patients were divided into the control group(n=35)and the study group(n=40)according to clinical medication.The control group was treated with Octreotide drugs,and the study group was treated with Octreotide combined with Propranolol.The effects of clinical treatment,adverse reactions and hemodynamics were compared between the two groups.Results The total effective rate of treatment in the study group was 92.50%,significantly higher than that in the control group(68.57%,P<0.05).After treatment,the results of central venous pressure,mean arterial pressure,portal vein blood flow and spleen venous blood flow were significantly better than those of the control group(P<0.05).The total inicidence of adverse reaction in the study group was 7.50%,which was significantly lower than that in the control group(22.86%),the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of Octreotide combined with Propranolol in the treatment of upper digestive tract hemorrhage in liver cirrhosis is significant and has high safety and positive clinical value.