利培酮联合奥氮平治疗精神分裂症的疗效及对患者认知功能的影响

Efficacy of Risperidon Combined with Olanzapine in Treatment of Schizophrenia and Its Effects on Cognitive Function

目的:探讨利培酮联合奥氮平治疗精神分裂症的疗效及对患者认知功能的影响。方法:选取2017年8月至2018年6月深圳市龙华区慢性病防治中心收治的精神分裂症患者130例作为研究对象,以随机数字表法分为观察组和对照组,每组65例。对照组患者仅给予利培酮治疗,观察组患者给予利培酮联合奥氮平治疗。观察两组患者的认知功能改善情况、临床疗效及不良反应发生情况。结果:治疗后,观察组、对照组患者平均临床记忆量表评分分别为(91.35±7.86)、(80.26±9.58)分,均明显高于治疗前,且观察组患者明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者的总有效率为93.85%(61/65),明显高于对照组的81.54%(53/65),差异有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为12.31%(8/65)、9.23%(6/65),差异无统计学意义(P>0.05)。结论:利培酮联合奥氮平治疗精神分裂症的疗效显著,可改善患者的认知功能,且不会增加过多不良反应。

OBJECTIVE: To probe into efficacy of risperidon combined with olanzapine in treatment of schizophrenia and its effects on cognitive function. METHODS: 130 patients with schizophrenia admitted into Shenzhen Longhua District Control and Prevention Center for Chronic Diseases from Aug. 2017 to Jun. 2018 were selected and divided into observation group via random number table, with 65 cases in each. The control group was treated with risperidon, while the observation group was given risperidon combined with olanzapine. The improvement of cognitive function, clinical efficacy and incidences adverse drug reactions of both groups were observed. RESULTS: After treatment, the average scores of clinical memory scale of observation group and control group were respectively(91.35±7.86) points and(80.26±9.58) points, which were significantly higher than those of before treatment, and that of observation group was significantly higher than the control group, with statistically significant differences(P<0.05); the total effective rate of observation group was 93.85%(61/65), which was significantly higher than that of the control group(81.54%, 53/65), with statistically significant difference(P<0.05). The incidences of adverse drug reactions of observation and control were respectively 12.31%(8/65) and 9.23%(6/65), the difference had no statistical significance(P>0.05). CONCLUSIONS: The efficacy of risperidon combined with olanzapine in treatment of schizophrenia is remarkable, which can improve patients’ cognitive function, with few adverse drug reactions.