缬沙坦胶囊联合社区生活方式干预治疗原发性高血压病的疗效观察

Observation on Efficacy of Valsartan Capsules Combined with Community Lifestyle Intervention on Patients with Essential Hypertension

目的:探讨缬沙坦胶囊联合社区生活方式干预治疗原发性高血压病的疗效。方法:回顾性选取2017年6—12月北京市海淀区东升镇社区卫生服务中心收治的轻中度原发性高血压病患者94例,按治疗方法的不同分为观察组48例和对照组46例。对照组患者给予硝苯地平控释片联合社区生活方式干预,观察组患者给予缬沙坦胶囊联合社区生活方式干预。观察两组患者的疗效、血压、心率、生活质量评分及不良反应发生情况。结果:观察组患者的总有效率为97.92%(47/48),明显高于对照组的78.26%(36/46),差异有统计学意义(P<0.05)。治疗后,观察组患者的收缩压、舒张压及心率较治疗前明显降低,且上述指标的改善程度明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,对照组、观察组患者平均生活质量评分分别为(69.85±14.86)、(70.03±14.77)分,较治疗前明显升高,差异均有统计学意义(P<0.05),但组间比较的差异无统计学意义(P>0.05)。两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:缬沙坦胶囊联合社区生活方式干预治疗原发性高血压病的疗效较好,可有效改善患者血压,提高患者生活质量,且安全性较好。

OBJECTIVE:To probe into the efficacy of Valsartan capsules combined with community lifestyle intervention on patients with essential hypertension. METHODS:94 patients with mild to moderate essential hypertension admitted into Beijing Haidian District Dongsheng Community Health Service Centre from Jun. to Dec. 2017 were retrospectively extracted to be divided into observation group(n=48) and control group(n=46) via different treatment methods. Patients in the control group were given Nifedipine controlled release tablets combined with community lifestyle intervention, while the observation group received Valsartan capsules in combination with community lifestyle intervention. The efficacy, blood pressure, heart rate, quality of life scores and adverse drug reactions of two groups were observed. RESULTS:The total effective rate of observation group was 97.92%(47/48), significantly higher than that of control group [78.26%(36/46)], the difference was statistically significant(P<0.05). After treatment, the systolic blood pressure, diastolic blood pressure and heart rate of the observation group were significantly lower than those before treatment, and the improvement of the above indicators were significantly better than those of the control group, and the difference was statistically significant(P<0.05). After treatment, the average quality of life scores of the control group and the observation group were(69.85±14.86) and(70.03±14.77) points, respectively, which were significantly higher than those before treatment(P<0.05), yet the difference between two groups was not statistically significant(P>0.05). There was no significant difference in the incidence of adverse drug reactions between two groups(P>0.05). CONCLUSIONS:The efficacy of Valsartan capsules combined with community lifestyle intervention on patients with essential hypertension is significant, which can effectively improve the blood pressure and the quality of life of patients with higher safety.