阿司匹林、氯吡格雷联合疏血通注射液治疗急性脑梗死的临床效果及对血液流变学的影响

The Clinical Effect of Aspirin,Clopidogrel Combined with Shuxuetong Injection on Acute Cerebral Infarction and its Effect on Hemorheology

目的探讨阿司匹林、氯吡格雷联合疏血通注射液治疗急性脑梗死的临床效果及对血液流变学的影响。方法选取2016年1月—2017年6月我院收治的急性脑梗死患者90例,采用随机数字表法分为观察组与对照组各45例,对照组采取阿司匹林肠溶片联合氯吡格雷片治疗,观察组在对照组基础上联合使用疏血通注射液,两组均连续治疗14 d。观察比较两组患者临床疗效、治疗前后血液流变学指标及治疗期间不良反应发生情况。结果治疗后观察组总有效率为88.89%高于对照组的66.67%(P<0.01)。治疗后,两组全血黏度(高切、低切),血浆黏稠度及纤维蛋白原含量均较治疗前降低,且治疗后观察组上述指标水平亦低于对照组,差异均有统计学意义(P<0.05或P<0.01)。两组患者均未发生脑出血、消化道出血等出血事件,且两组治疗期间不良反应发生率比较差异无统计学意义(P> 0.05)。结论阿司匹林、氯吡格雷联合疏血通注射液治疗急性脑梗死的效果显著,并能有效改善患者血液流变学指标,应用安全性好。

Objective To investigate the clinical effect of aspirin,clopidogrel combined with Shuxuetong injection on acute cerebral infarction(ACI)and its influence on hemorheology.Methods Ninety patients with ACI treated in our hospital from January 2016 to June 2017 were selected as the research subjects,and they were randomly divided into the observation group(n=45)and the control group(n=45)using random number table method.The control group was treated with Aspirin Enteric-coated Tablets combined with Clopidogrel Bisulfate Tablets,and the observation group was given Shuxuetong Injection on the basis of the control group.Both groups were treated for 14 consecutive days.The clinical efficacy,hemorheological indexes before and after treatment and adverse reactions during treatment were observed and compared between the two groups.Results After treatment,the total effective rate of the observation group was 88.89%,which was higher than that(66.67%)of the control group(P<0.01).After treatment,the blood viscosity of two groups(high and low shear),plasma viscosity and FIB content were lower than those before treatment,and the indexes of observation group were lower than those in control group(P<0.05 or P<0.01).There were no bleeding events such as cerebral hemorrhage and gastrointestinal bleeding in the two groups,and there was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Aspirin and clopidogrel combined with Shuxuetong injection are effective in the treatment of ACI,which can effectively improve hemorheological parameters,with good safety and reliability.