水合氯醛与右美托咪定用于儿科MRI检查镇静的临床观察

Clinical observation on chloral hydrate and dexmedetomidine for pediatric MRI inspection sedation

目的观察水合氯醛与右美托咪定用于儿科MRI检查的镇静效果及不良反应。方法随机选取择期住院行MRI检查的患儿52例,年龄1～3岁,ASAⅠ～Ⅱ,随机分为2组(CH组和DEX组),CH组口服水合氯醛60 mg/kg,DEX组经鼻滴右美托咪定2μg/kg。记录二组患儿生命体征、入睡和苏醒时间、镇静评分及镇静不良反应的发生率。结果两组患儿一般情况及生命体征变化比较,差异无统计学意义(P>0.05);DEX组在入睡和苏醒时间、镇静评分上显著优于CH组(P<0.05),在不良反应发生方面,DEX组在恶心呕吐、苏醒期躁动、镇静成功率、及检查后二次镇静发生率方面显著低于CH组(P<0.05)。结论右美托咪定滴鼻用于儿童镇静成功率高、苏醒质量好、不良反应发生率低。

Objective To observe the sedative effect and adverse events of chloral hydrate and dexmedetomidine for pediatric MRI.Methods The 52 children-patients to be subject to schedule MRI during hospitalization were randomly enrolled in this study(age 1-3,ASAⅠ-Ⅱ),and divided into 2 groups(CH group and DEX group);CH group was orally administerel chloral hydrate 60mg/kg,and DEX group was intranasally did dexmedetomidine 2μg/kg.The vital signs,sleep and wakefulness time,sedation score,and Sedation success rate were recorded in the two groups.Results There was no significant difference in the general condition and vital signs between the two groups(P>0.05),compared with the CH group.The DEX group was significantly better than the CH group in the time of falling asleep and recovery,and the sedation score(P<0.05).In the incidence of adverse events,the incidence of vomiting,agitation,Sedation success rate,and secondary sedation in the DEX group significantly lower than in CH group(P<0.05).Conclusion Dexmedetomidine nasal drops can achieve high sedation success rate and good recovery quality.The incidence of adverse events is low.