不同剂量舒芬太尼对胆囊癌手术患者预后的影响

Study on the Efficacy of Different Doses of Sufentanil for Patients with Gallbladder Cancer

目的探讨不同剂量麻醉药物(舒芬太尼)对胆囊癌手术患者预后的影响。方法选取行手术治疗胆囊癌的患者160例作为研究对象,根据术中舒芬太尼用量分为观察组(80例)和对照组(80例)。2组患者均采用静脉途径给药,剂量分别为0.15 g/kg和0.20 g/kg。对2组患者的手术疗效、苏醒时间、并发症以及术后1 h、4 h和12 h的镇痛和镇静评分进行比较。结果 2组患者的总有效率差异无统计学意义(P> 0.05)。观察组的苏醒时间[(10.91±1.94)min]低于对照组[(14.42±2.13) min],差异有统计学意义(P <0.05)。观察组术后1 h、4 h、12 h的镇静评分及1 h、4 h的镇痛评分与对照组相比,差异显著(P <0.05);但12 h的镇痛评分与对照组相比,差异无统计学意义(P> 0.05)。观察组术后并发症发生率显著低于对照组(P <0.05)。结论胆囊癌患者术中给予0.15 g/kg的舒芬太尼术后苏醒时间明显较短,镇痛和镇静效果较好,并发症发生率低。

Objective To investigate the prognostic significance of surgical treatment of patients with gallbladder cancer with different doses of anesthetic( sufentanyl).Methods 160 patients who underwent surgery to treat gallbladder cancer during the period were divided into observation group( 80 cases) and control group( 80 cases) according to the sufentanyl dosage.The observation group and control group were given sufentanyl as 0.15 g/kg and 0.20 g/kg through intravenous a Dministration.The efficacy,waking time,complications and analgesic and sedative scores of 1 h,4 h and 12 h were compared between the groups.Results The total efficiency of the two groups was not statistically significant( P > 0.05).The wake time of the observation group( 10.91 ± 1.94) minutes was lower than the control group( 14.42 ± 2.13) minutes,and the difference was statistically significant( P < 0.05);The sedation score of 1 h,4 h and 12 h and the analgesic score of 1 hour and 4 hour of the observation group were significantly different from that of the control group( P < 0.05),the analgesic score of 12 hour showed no statistical significance compared with the control group( P > 0.05).The complication rate of the observation group was significantly lower than that of the control group( P < 0.05).Conclusion The postoperative anesthetic effect of patients with gallbladder cancer who given sufentanyl with 0.15 g/kg was significantly better than 0.20 g/kg.