序贯疗法与三联疗法治疗幽门螺杆菌阳性胃溃疡观察

Comparison of Sequential Therapy and Standard Triple Therapy in the Treatment of Helicobacter Pylori Positive Gastric Ulcer

目的探讨序贯疗法与标准三联疗法治疗幽门螺杆菌阳性胃溃疡的临床效果。方法选取我院2015年1月—2017年1月收治的幽门螺杆菌阳性胃溃疡患者98例为研究对象,随机分为两组,观察组(n=49)给予序贯疗法治疗,对照组(n=49)给予标准三联疗法治疗,对比两组患者临床疗效和胃溃疡愈合情况以及不良反应发生率。结果两组患者临床疗效(95.92%/83.67%)对比差异具有统计学意义(P <0.05)。两组患者胃溃疡愈合率(93.88%/75.51%)对比差异具有统计学意义(P<0.05)。两组患者不良反应发生率(10.20%/12.24%)对比差异无统计学意义(P> 0.05)。结论序贯疗法治疗幽门螺杆菌阳性胃溃疡效果优于标准三联法,能有效清除幽门螺杆菌,促进胃溃疡愈合,安全性高。

Objective To compare the clinical effects of sequential therapy and standard triple therapy in the treatment of helicobacter pylori positive gastric ulcer.Methods From January 2015 to January 2017,98 patients with helicobacter pylori-positive gastric ulcer were randomly divided into two groups.The observation group(n=49)was treated with sequential therapy,and the control group(n=49)was treated with standard triple therapy.The clinical efficacy,gastric ulcer healing and the incidence of adverse reactions were compared between the two groups.Results The clinical efficacy of the two groups(95.92%/83.67%)was compared,the difference was statistically significant(P<0.05).The healing rate of gastric ulcer in the two groups(93.88%/75.51%)was compared,the difference was statistically significant(P<0.05).The incidence of adverse reactions(10.20%/12.24%)was compared between the two groups,there was no significant difference(P>0.05).Conclusion Sequential therapy is better than standard triple therapy in the treatment of helicobacter pylori positive gastric ulcer.It can effectively eliminate helicobacter pylori and promote the healing of gastric ulcer.