运动康复联合曲美他嗪对冠心病患者PCI术后内皮功能、炎症反应及血脂代谢的影响

Effect of exercise rehabilitation combined with trimetazidine on endothelial function,inflammatory response and blood lipid metabolism in patients with coronary heart disease after PCI

目的:研究运动康复联合曲美他嗪对冠心病患者经皮冠状动脉介入术(PCI)术后内皮功能、炎症反应及血脂代谢的影响。方法:选择在我院接受PCI的稳定型心绞痛患者,随机分为接受术后运动康复联合曲美他嗪的观察组、常规干预联合曲美他嗪的对照组。干预前及干预后3个月,测定反应性充血指数(RHI)及血清内皮标志物、炎症细胞因子、血脂指标的含量。结果:干预后3个月时,两组的RHI水平及血清NO、HDL-C、Omentin-1含量均明显升高,血清ET-1、vWF、M-CSF、IL-6、IL-8、RANTES、LDL-C、Chemerin的含量均明显降低且观察组的RHI水平及血清NO、HDL-C、Omentin-1含量均明显高于对照组,血清ET-1、vWF、M-CSF、IL-6、IL-8、RANTES、LDL-C、Chemerin的含量均明显低于对照组。结论:冠心病患者PCI术后进行运动康复联合曲美他嗪治疗能够改善内皮功能、抑制炎症反应、调节血脂代谢。

Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function,inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods:The patients with stable angina pectoris who received PCI in our hospital between July 2015 and November 2017 were chosen and randomly divided into the observation group who received postoperative exercise rehabilitation combined with trimetazidine and the control group who received conventional intervention combined with trimetazidine.The reactive hyperemia index(RHI)as well as serum contents of endothelial markers,inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months,the RHI levels as well as serum NO,HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1,vWF,M-CSF,IL-6,IL-8,RANTES,LDL-C and Chemerin contents significantly decreased;the RHI level as well as serum NO,HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1,vWF,M-CSF,IL-6,IL-8,RANTES,LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function,inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI.