妥布霉素滴眼液与氧氟沙星滴眼液治疗儿童急性结膜炎的临床比较研究

Study on clinical comparison of tobramycin eye drops and ofloxacin eye drops in the treatment of children with acute conjunctivitis

目的研究在儿童急性结膜炎的治疗中妥布霉素滴眼液与氧氟沙星滴眼液的临床效果。方法 84例急性结膜炎患儿,根据治疗方法不同分为对照组和观察组,每组42例。对照组患儿使用氧氟沙星滴眼液治疗,观察组患儿使用妥布霉素滴眼液治疗。对比两组患儿的临床效果及不良反应发生情况、复发情况。结果观察组患儿总有效率为95.2%,高于对照组的78.6%,差异具有统计学意义(P<0.05)。观察组患儿复发率为7.1%、不良反应发生率为2.4%,均低于对照组的26.2%、16.7%,差异具有统计学意义(P<0.05)。结论在儿童急性结膜炎治疗中,妥布霉素滴眼液的临床效果更为明显,且具有较高的安全性,适合应用。

Objective To study the clinical effect of tobramycin eye drops and ofloxacin eye drops in the treatment of children with acute conjunctivitis. Methods A total of 84 children with acute conjunctivitis were divided by different treatment methods into control group and observation group, with 42 cases in each group. The control group was treated with ofloxacin eye drops, and the observation group was treated with tobramycin eye drops. The clinical effect, occurrence of adverse reactions and recurrence condition in two groups was compared. Results The observation group had higher total effective rate as 95.2% than 78.6% in the control group, and the difference was statistically significant(P<0.05). The observation group had lower recurrence rate as 7.1% and incidence of adverse reactions as 2.4% than 26.2% and 16.7% in the control group, and their difference was statistically significant(P<0.05). Conclusion Tobramycin eye drops shows more obvious clinical effect in treating children with acute conjunctivitis with high safety. It is worthy of application.