经皮椎体成形术在脊柱转移瘤应用疗效的Meta分析

Meta analysis on curative effect of percutaneous vertebral plasty for spinal metastasis

目的 系统评价经皮椎体成形术在脊柱转移瘤中应用的疗效性。方法 计算机检索PubMed、Science Direct Online、Springer、CNKI、万方和维普,搜集有关临床研究(Clinical Trial)。由2位研究者按照纳入与排除标准筛选文献、提取资料和评价质量后,采用Stata 12.0软件进行Meta分析。结果 共纳入33个临床研究,共有1 727例患者,椎体数2 546。Meta分析结果显示:术后1周、1月、3月VAS评分差异有统计学意义(均P<0.05);术中骨水泥渗漏平均发生率21%,术后平均生活明显改善率为85%。结论 经皮椎体成形术作为一种微创手术,能够早期和长期缓解因脊柱转移瘤引起的难治性疼痛,有效改善恶性肿瘤患者晚期生活质量。

Objective To systematically evaluate the efficacy of percutaneous vertebral plasty in the treatment of spinal metastatic tumors.Methods The databases of PubMed,Science Direct Online,Springer,CNKI,Wanfang,and Vip were retrieved,and the relevant clinical studies were collected.After the two researchers had screened the literatures,the data were extracted and the quality was evaluated according to the inclusion and exclusion criteria.The Meta analysis was carried out using Stata 12.0 software.Results 33 clinical studies were included,with a total of 1 727 patients and 2 546 vertebral bodies.The Meta analysis showed that there were statistical differences in VAS score 1 week and 1 and 3 months after operation(P<0.05).The average rate of intraoperative bone cement leakage was 21%,and the average rate of life improvement after operation was 85%.Conclusions Percutaneous vertebral plasty,as a minimally invasive procedure,can relieve refractory pain caused by spinal metastasis in the early stage and long-term,and can improve the life quality in patients with malignant tumors.