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Effects of yiqi yangyin huoxue therapy on IgA nephropathy: a systematic review and meta-analysis of randomized controlled trials 被引量:1

Effects of yiqi yangyin huoxue therapy on IgA nephropathy: a systematic review and meta-analysis of randomized controlled trials
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摘要 Objective To assess the efficacy and safety of Yiqi Yangyin Huoxue therapy (YYHT) for the treatment of IgA nephropathy. Methods Databases articles about YYHT in treating IgAN patients were searched through February 2018. Comparisons were YYHT alone or YYHT in combination with western medicine as experimental intervention, and western medicine as the control. Randomized controlled trials (RCTs) were selected. Cochrane collaboration tool was used for assessing risk of bias to evaluate methodologies. RevMan 5.3 software was applied to analyze the data of included trials. Results A total of 21 studies involving 1473 patients were included. Meta-analysis results demonstrated that YYHT alone or YYHT in combination with western medicine were more efficacious than only western medicine in decreasing proteinuria [MD =-0.41, 95% CI (-0.53,-0.29), P < 0.00001] and the urine red blood cells [MD =-7.46, 95% CI (-9.28,-5.64), P < 0.00001]. There also showed improvement in the clinical total effective rate [OR = 2.78, 95% CI (2.14, 3.61), P < 0.00001] between the two groups. Some of the included trials did not report the adverse events. Conclusions Current evidence shows that YYHT can reduce proteinuria and urine red blood cells and improve the total efficacy rate. Since poor quality and publication bias of some included trials, more evidence-based medicine studies needed to define the role of YYHT in the treatment of IgAN. 评估益气养阴活血法治疗IgA肾病的疗效和安全性。方法:2018年2月检索关于益气养阴活血法治疗IgA肾病的数据库文献。以益气养阴活血法单独或联合西药作为实验干预,以西药作为对照的随机对照试验。Cochrane协作工具用于评估偏倚风险,以评估方法学质量。应用RevMan5.3软件对纳入的试验数据进行分析。结果:共纳入21项研究,涉及1473例患者。Meta分析结果显示,单用益气养阴活血法或益气养阴活血法联合西药较单独西药治疗蛋白尿[MD=-0.41,95%CI(-0.53,-0.29),P<0.00001]及尿红细胞[MD=-7.46,95%CI(-9.28,-5.64),P<0.00001]疗效更加显著,临床总有效率也有所提高[OR=2.78,95%CI(2.14,3.61),P<0.00001]。其中一些试验没有报告不良反应。结论:目前研究表明益气养阴活血法能降低蛋白尿和尿红细胞,提高总有效率。由于一些实验的质量和出版偏倚很差,需要更多的循证医学研究来明确益气养阴活血法在治疗IgA肾病中的作用。
出处 《TMR Theory and Hypothesis》 2018年第4期106-116,共11页 TMR理论与假说
关键词 Yiqi Yangyin Huoxue therapy IgA nephropathy META-ANALYSIS Systematic review 益气养阴活血疗法 IgA肾病 荟萃分析 系统评价
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