普拉洛芬联合羧甲基纤维素钠滴眼液治疗中重度干眼症的疗效观察

Curative Effect of Pranoprofen combined with Carboxymethylcellulose Sodium Eye Drops in the treatment of Moderate to Severe Dry Eye

目的:观察普拉洛芬联合羧甲基纤维素钠滴眼液治疗中重度干眼症的临床治疗效果。方法:选取2018年1月至2018年8月眼科门诊治疗的中重度干眼症患者100例,随机分为50例采用普拉洛芬配合羧甲基纤维素钠滴眼液治疗的联合组和50例采用羧甲基纤维素钠滴眼液治疗的对照组,疗程持续6周,研究两组病患人员在治疗前后SIT、BUT、FL评分、干眼程度评分、治疗效果及不良反应(刺激、视线模糊、充血)发生情况。结果:联合组治疗后SIT、BUT、FL评分及干眼程度评分与对照组相比显著提高(P<0.05);联合组治愈率、治疗总有效率高于对照组(P<0.05);联合组不良反应总发生率显著低于对照组(P<0.05)。结论:普拉洛芬联合羧甲基纤维素钠滴眼液治疗中重度干眼症患者疗效显著,且安全性良好,具有临床推广意义。

Objective:To observe the clinical curative effect of pranoprofen combined with carboxymethylcellulose sodium eye drops in the treatment of moderate to severe dry eye.Methods:100 patients with moderate to severe dry eye treated in the ophthalmology clinic of the hospital from January to August 2018 were randomly divided into the combined group(50 patients treated with pranoprofen combined with carboxymethylcellulose sodium eye drops)and the control group(50 patients treated with carboxymethylcellulose sodium eye drops).The SIT,BUT and FL scores before and after treatment,dry eye scores,curative effect and incidence of adverse reactions in both groups were observed.Results:The SIT,BUT and FL scores and dry eye score of the combined group were significantly lower than those of the control group after treatment(P<0.05).The cure rate and the total effective rate of the combined group were higher than those of the control group.The overall incidence of adverse reactions in the combined group was significantly lower than that in the control group(P<0.05).Conclusion:Praprofene combined with carboxymethylcellulose sodium eye drops is effective in the treatment of moderate to severe dry eye,with safety.