氯沙坦联合雷公藤多苷片治疗糖尿病肾病的临床疗效及尿微量白蛋白等指标的影响

The Clinical Efficacy of Losartan Combined with Tripterygium Glycosides in the Treatment of Diabetic Nephropathy and the Influence of Urine Microalbumin and Other Indicators

目的观察氯沙坦联合雷公藤多苷片治疗糖尿病肾病的临床疗效及尿微量白蛋白等指标的影响。方法选取2016年6月—2018年6月该院收治的糖尿病肾病患者62例,常规组应用氯沙坦进行治疗,试验组应用氯沙坦联合雷公藤多苷片进行治疗,每组31例。对比2组患者治疗后临床效果及尿微量白蛋白指标的差异性。结果治疗后,试验组治疗有效率为83.87%,明显高于常规组的51.61%,差异有统计学意义(χ2=7.38,P<0.05);治疗后,试验组患者24 h尿白蛋白、血肌酐、尿素氮指标水平分别为(52.05±7.11)mg/24 h、(55.17±6.24)μmol/L、(5.05±1.11)mmol/L,相比治疗前明显改善(P<0.05),且改善情况明显优于常规组,差异有统计学意义(t=74.05,9.76,3.99,P<0.05)。结论氯沙坦联合雷公藤多苷片治疗糖尿病肾病的临床疗效及尿微量白蛋白等指标的影响显著,可推广应用。

Objective To observe the clinical efficacy of losartan combined with tripterygium glycosides in the treatment of diabetic nephropathy and the influence of urine microalbumin. Methods 62 patients with diabetic nephropathy admitted to our hospital from June 2016 to June 2018 were enrolled. The routine group was treated with losartan. The test group was treated with losartan combined with tripterygium glycosides. 31 cases in each group. The clinical effects and urinary microalbumin index differences between the two groups were compared. Results After treatment, the effective rate of the experimental group was 83.87%, which was significantly higher than 51.61% of the conventional group,the different was statistically significant (χ^2=7.38, P<0.05). After treatment, the level of urinary albumin of 24 h, serum creatinine and urea nitrogen in the experimental group were (52.05±7.11)mg/24 h,(55.17±6.24)μmol/L,(5.05±1.11)mmol/L, which was significantly improved compared with before treatment (P <0.05), and the improvement was significantly better than the conventional group,the different was statistically significant (t =74.05,9.76, 3.99, P <0.05). Conclusion The clinical effects of losartan combined with tripterygium glycosides in the treatment of diabetic nephropathy and the effects of urinary microalbumin are significant and can be applied.