肠道菌群与胆汁酸的相互作用在炎症性肠病中的研究

Study on interaction between bile acid and gut microbiota in inflammatory bowel disease

炎症性肠病(inflammatory bowel disease, IBD)是一种慢性非特异性肠道炎症性疾病,主要包括溃疡性结肠炎(ulcerative colitis, UC)和克罗恩病(Crohn’s disease, CD)。IBD的发生极有可能是遗传、感染、环境、免疫等相互作用造成的。胆汁酸与肠道菌群在病理情况下的相互作用损伤了宿主体内正常的生物转化过程,扰乱正常信号通路,破坏宿主内环境稳态,逐渐被认为是导致IBD发生的原因之一。本文旨在对近年来胆汁酸与肠道菌群在IBD发生、发展过程中相互作用的研究及胆汁酸、微生态制剂在IBD治疗中的应用进行总结,为临床防治IBD提供有效信息。

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn’s disease (CD). It is highly likely that the occurrence of IBD is caused by the interaction of heredity, infection, environment and immunity. Interaction between bile acid and gut microbiota under pathological status damages the process of normal biotransformation, disrupts the normal signaling pathway and destroys the homeostasis of the internal environment in the host, which is gradually considered to be one of the causes of IBD. In this article, we summarized the research of the interaction between bile acid and gut microbiota in the occurrence and development of IBD in recent years, as well as the content of bile acid and microecological agent for the treatment of IBD, providing effective information for clinical prevention and treatment of IBD.