中老年脑卒中患者握力与认知功能的关系探讨:来自中国健康与退休前瞻性队列研究

Association between Grip Strength and Cognitive Function among Middle-aged and Older Adults with Stroke:Findings from the China Health and Retirement Longitudinal Study

目的本研究旨在评估握力与认知功能在中老年脑卒中患者中的关系。方法本研究采用中国健康与退休前瞻性队列研究(CHARLS)中412例脑卒中患者2011年至2012年的基线调查数据,分析脑卒中患者握力与认知功能的关系以及性别的影响。结果握力可增加认知功能得分。每增加5 kg握力,脑卒中患者能够正确画出图案的概率增加30%(95%CI:8%～57%, P=0.005)。同时,情节记忆增加0.15分(P=0.003),电话筛查认知功能增加0.30分(P=0.001),总认知得分增加0.60分(P <0.001)。握力与所有认知指标的关系在女性脑卒中患者中更强,尤其是情节记忆得分方面具有性别差异(P=0.049)。结论握力与认知能力的各项指标均呈正相关。握力对认知功能的作用在女性脑卒中患者中的作用更大。

Objective To explore the relationship between grips strength and cognitive function among stroke patients in China. Methods The data of 412 post-stroke participants from the baseline survey of the China Health and Retirement Longitudinal Study (CHARLS) were selected. The association between grip strength and cognitive function was analyzed , especially in gender. Results Grip strength was positively associated with all cognitive measures. For every 5 kg increase in grip strength, the likelihood increased 30% in correctly drawing picture (95%CI: 8%-57%, P = 0.005);and the scores increased 0.15 points in episodic memory (P = 0.003), 0.30 points in Telephone Interview of Cognitive Status (TICS-10)(P = 0.001), and 0.60 points (P < 0.001) in the overall cognition scores. The association between grip strength and cognitive measures was stronger among female patients, particularly for episodic memory (P = 0.049). Conclusion Grip strength was positively associated with cognitive function among stroke patients. The association was stronger among female patients.