血清CA19-9联合CT检查胰腺癌的临床价值分析

Diagnostic value of combined serum CA19-9 with CT scanning in patients with pancreatic cancer

目的探讨血清肿瘤标志物CA19-9检测联合CT检查诊断胰腺癌的临床应用价值。 方法选取2012年5月至2016年12月在我院进行CT检查结果为可疑胰腺癌的患者89例,统计血清CA19-9在诊断胰腺癌方面的特异度、敏感度、阳性预测值及阴性预测值。分析术前术后血清CA19-9水平与手术切除患者的生存期关系。 结果血清CA19-9联合CT检查在诊断胰腺癌特异度为97.2%,敏感度为86.4%,阳性预测值为100.0%,阴性预测值为94.0%。随着术前血清CA19-9水平不断升高,胰腺癌切除率逐渐下降,术后中位生存期逐渐降低。术后血清CA19-9水平降至正常范围的患者,其生存期长于未降至正常者。 结论血清CA19-9作为胰腺癌肿瘤标志物之一,诊断敏感度较高,结合影像学CT检查能大幅提高胰腺癌的诊断正确率。CA19-9还能作为胰腺癌根治切除术后疗效评价手段。

Objective To evaluate the diagnostic value of combined serum tumor marker CA19-9 with CT scanning in the patients with pancreatic cancer. Methods A total of 89 patients with suspected pancreatic cancer diagnosed by CT scanning were selected at our hospital from May 2012 to December 2016.The detected results of serum CA19-9 were recorded, and the specificity, sensitivity, positive and negative predictive value of serum CA19-9 in the diagnosis of pancreatic cancer were statistically calculated and analyzed.The correlations between the pre- and post-operative serum levels of CA19-9 and the survival time in pancreatic cancer patients undergoing operation were analyzed. Results The specificity, sensitivity, positive predictive value and negative predictive value of serum CA19-9 combined with CT scanning in the diagnosis of pancreatic cancer were 97.2%, 86.4%, 100.0%, 94.0% respectively.With the increase of preoperative serum levels of CA19-9, the resection rate and median postoperative survival time gradually decreased.Patients with normal serum levels of CA19-9 after operation had longer postoperative survival time than patients with high postoperative serum levels of CA19-9. Conclusions As one of the tumor markers of pancreatic cancer, serum CA19-9 detection has a high diagnostic sensitivity.Combined with CT scanning, serum CA19-9 detection can significantly improve the diagnostic accuracy of pancreatic cancer.Serum CA19-9 can also be used as a mean of efficacy evaluation after radical resection of pancreatic cancer.