高血压特征代谢物组研究进展及其在中医证候分型中的应用

Research Progress on Characteristic Metabolites of Hypertension and its Application in Syndrome Differentiation of TCM

高血压是最常见的慢性非传染性疾病,是心血管疾病的主要危险因素。已有研究表明,代谢紊乱是现代高血压病发病的重要环节。代谢组学作为检测体内代谢物的技术之一,可以反应不同状态下体内代谢物组水平的变化,已应用于探索高血压诊断、预防和治疗的生物标志物。同时,中医对于高血压进行辨证论治和整体治疗是高血压中医诊疗的特色。本文首先综述了高血压特征性代谢物组研究进展,并对利用代谢组学技术在高血压证候分型中的应用也进行了介绍,以期为高血压证候研究提供现代科学基础。

Hypertension is the most common chronic non-communicable disease and is a major risk factor for cardiovascular disease. Researches show that the metabolic disorder is a significant cause of hypertension. The in vivo metabolites detecting technique and metabonomics can be used to reflect the metabolites levels in different states of body. Therefore, metabonomics has been applied as biomarkers for early diagnosis, prevention, and treatment of hypertension. Treatment based on syndrome differentiation and holistic treatments are characteristics of the traditional Chinese medicine(TCM) diagnosis and treatment. This article reviews the advances in the study of characteristic metabolites in hypertension, and introduces the use of metabonomics techniques in the classification of hypertension syndrome to provide a modern scientific basis for hypertension syndrome research.Hypertension is the most common chronic non-communicable disease and is a major risk factor for cardiovascular disease. Researches show that the metabolic disorder is a significant cause of hypertension. The in vivo metabolites detecting technique and metabonomics can be used to reflect the metabolites levels in different states of body. Therefore,metabonomics has been applied as biomarkers for early diagnosis,prevention,and treatment of hypertension. Treatment based on syndrome differentiation and holistic treatments are characteristics of the traditional Chinese medicine( TCM) diagnosis and treatment. This article reviews the advances in the study of characteristic metabolites in hypertension,and introduces the use of metabonomics techniques in the classification of hypertension syndrome to provide a modern scientific basis for hypertension syndrome research.