持续气道正压通气联合银杏叶提取物对急性脑梗死合并阻塞性睡眠呼吸暂停综合征患者的疗效和安全性分析

Efficacy and safety of continuous positive airway pressure combined with ginkgo biloba extract in patients with acute cerebral infarction complicated with obstructive sleep apnea syndrome

目的探讨持续气道正压通气(CPAP)联合银杏叶提取物对急性脑梗死合并阻塞性睡眠呼吸暂停综合征(OSAHS)患者的临床疗效和安全性。方法将95例急性脑梗死合并OSAHS患者随机分为观察组48例和对照组47例,所有患者入院后均给予常规疗法,对照组在此基础上给予CPAP,观察组在对照组基础上加用银杏叶提取物注射液。比较治疗前后两组患者血液流变学、血脂代谢、经颅彩色多普勒超声(TCD)双侧颅内动脉阻力指数(RI)和炎症因子的差异,并统计不良反应发生率。结果两组治疗后血液流变学、血脂代谢、TCD双侧颅内动脉RI和炎症因子水平均得到显著改善(P<0.05,P<0.01),两组治疗后HDL-C和LDL-C水平差异无统计学意义(P>0.05),其余指标观察组治疗后均优于对照组(P<0.05,P<0.01)。两组不良反应均较轻微。结论 CPAP联合银杏叶提取物注射液可更为显著地改善急性脑梗死合并OSAHS患者的血液流变学、血脂代谢、脑血流动力学和炎症因子水平,且安全性较好,可在临床推广应用。

Objective To investigate the clinical efficacy and safety of continuous positive airway pressure ( CPAP) combined with ginkgo biloba extract in patients with acute cerebral infarction complicated with obstructive sleep apnea syndrome ( OSAHS). Methods Ninety-five patients with acute cerebral infarction and OSAHS were randomly divided into observation group ( n = 48) and control group ( n = 47). All patients were given conventional therapy after admission. The control group was given CPAP on this basis. The observation group was added on the basis of the control group. Ginkgo biloba extract injection. The differences of hemorheology,lipid metabolism,transcranial color Doppler ultrasound ( TCD) bilateral intracranial arterial resistance index ( RI) and inflammatory factors were compared between the two groups before and after treatment,and the incidence of adverse reactions was statistically analyzed. Results After treatment,blood rheology,lipid metabolism,TCD bilateral intracranial artery RI and inflammatory factor levels were significantly improved ( P < 0. 05,P < 0. 01). HDL-C and LDL-C levels after treatment. The difference was not statistically significant ( P > 0. 05),and the other indicators were significantly better than the control group after treatment ( P < 0. 05,P < 0. 01). The adverse reactions in both groups were mild. Conclusion CPAP combined with Ginkgo biloba extract can significantly improve the blood rheology,lipid metabolism,cerebral hemodynamics and inflammatory factors in patients with acute cerebral infarction complicated with OSAHS,and it is safe and can be promoted in clinical practice. application.