阿奇霉素治疗生殖道沙眼衣原体感染的临床疗效观察

Observation on clinical curative effects of azithromycin in treatment of reproductive canal chlamydia trachomatis infection

目的研究生殖道沙眼衣原体感染患者采用阿奇霉素治疗的临床效果。方法临床纳入256例我院2017年1～12月期间收治的生殖道沙眼衣原体感染患者作为研究对象,采用随机数字表法分为两组,各128例。其中128例患者采用阿奇霉素口服治疗作为观察组,另128例患者采用强力霉素口服治疗作为对照组。观察两组患者治疗效果、生活质量、不良反应以及用药时间情况。结果观察组治疗总有效率(82.03%)与对照组治疗总有效率(77.34%)比较,差异无统计学意义(P> 0.05)。治疗前两组患者日常生活能力量表(Activity of Daily Living Scale,ADL)、生活质量量表(Quality of Life,QOL)评分比较,差异无统计学意义(P> 0.05);治疗后两组ADL、QOL评分均高于治疗前,差异无统计学意义(P> 0.05)。观察组不良反应发生率(15.63%)明显低于对照组发生率(27.34%),差异有统计学意义(P <0.05)。结论阿奇霉素与强力霉素对生殖道沙眼衣原体感染均有较好效果,可明显改善患者生活质量,但阿奇霉素用药时间更短,不良反应更低,可作为临床治疗生殖道沙眼衣原体感染的首选方案。

Objective To study clinical curative effects of azithromycin in the treatment of patients withreproductive canal chlamydia trachomatis infection. Methods 256 patients with reproductive canal chlamydia trachomatis infectionwho were admitted to our hospital from January 2017 to December 2017 were included in the clinical study as research objects. According to the random number table method, they were divided into two groups, with 128 cases in each group. Among them, 128 patients who were treated with azithromycin orally were set as the observation group while the other 128 patients who were treated with doxycycline orally were set as the control group. The curative effect, quality of life, adverse reactions and medication time of patents in two groups were observed. Results There was no statistically significant difference in the total effective rate between the observation group (82.03%)and the control group (77.34%),(P > 0.05).There was no statistically significant difference in the scores of Activity of Daily Living Scale (ADL) and Quality of Life (QOL) between the two groups before treatment (P > 0.05).The scores of ADL and QOL in the two groups were higher than those before treatment, but there was no statisticallysignificant difference between the two groups (P > 0.05).The incidence of observation group (15.63%) was significantly lower than that of the control group (27.34%), and the difference was statistically significant (P < 0.05). Conclusion Azithromycin and doxycycline both have good curative effects in treatment of reproductive canal chlamydia trachomatis infection, which can significantly improve the quality of life of patients. However, azithromycin has shorter medication time and lower adverse reactions. Therefore, it can be used as the first choice for clinical treatment of reproductive canal chlamydia trachomatis infection.