酪酸梭菌肠球菌三联活菌片合并常规三联方案根治HP对胃增生性息肉的治疗作用

Therapeutic Effect of Clostridium Caseate Enterococci Combined with Routine Triple Regimen for HP on Gastric Hyperplastic polyps Polyps

目的研究酪酸梭菌肠球菌三联活菌片合常规三联药物根除幽门螺杆菌(Helicobacter pylori,Hp)对胃增生性息肉的疗效。方法回顾性方便收集2013年1月—2017年6月期间东莞市第八人民医院胃增生性的息肉合并HP感染的60例患者的临床资料,采用随机数字表分为两组,其中第1组为治疗组,有30例患者,给予酪酸梭菌肠球菌三联活菌片、泮托拉唑肠溶胶囊、克拉霉素片、阿莫西林胶囊治疗,疗程2周。第2组为对照组,有30例患者,给予泮托拉唑肠溶胶囊、克拉霉素片、阿莫西林胶囊治疗,疗程2周。结果第1组HP根除率达83.3%(25例)),随访1年,有22例患者胃息肉消失,有7例患者胃息肉有不同程度较少减少或缩小,均出现在HP根除者中,治疗有效率96.7%。第2组有24例HP根除,根除率80.0%,随访1年,有19例胃息肉消失,有4例患者胃息肉有不同程度较少减少或缩小,均出现在HP根除者中,治疗有效率79.7%。两组患者在HP根除率比较差异无统计学意义(χ~2=0.111,P>0.05),治疗有效率方面比较差异有统计学意义(χ~2=5.192,P<0.05)。两组患者在治疗过程中出现的胃肠道不良反应中比较差异有统计学意义,如恶心(χ~2=5.934,P=0.015)、呕吐(χ~2=19.200,P值=0.000)、腹泻(χ~2=9.017,P=0.03)、便秘,两组比较差异有统计学意义(χ~2=5.455,P<0.05);在皮疹、口腔异味的不良反应中,两组比较差异无统计学意义(χ~2=0.000、P=0.754;χ~2=0.067、P=0.500)。结论胃增生性息肉与Hp感染相关,酪酸梭菌肠球菌三联活菌片联合常规三联方案根治HP治疗胃增生性息肉疗效显著,同时能减轻消胃肠道不良反应。

Objective To study the efficacy of Clostridium caseoides Enterococcus trinufaciens tablets combined with conventional triple drug eradication (Helicobacter pylorius HP) in the treatment of gastric proliferative polyps.. Methods Clinical data of 60 patients with gastric hypertrophic polyp combined with HP infection in Dongguan eighth people's hospital from January 2013 to June 2017 were convenient collected retrospectively. they were divided into two groups by random number table, the first group was the treatment group, there were 30 patients, patients were treated with clostridium butyricum enterococcus triple viable tablets, pantoprazole enteric-coated capsules, clarithromycin tablets and amoxicillin Capsules, two weeks of treatment. The second group was the control group, there were 30 patients too, pantoprazole enteric-coated capsules, clarithromycin tablets and amoxicillin capsules were given, two weeks of treatment. Results TheHP The HP eradication rateof rate of the first group was 83.3%(25 cases).One years after the follow-up, 22 patients with gastric polyps disappeared, there were 7 cases of smaller gastric polyps, all appeared in the HP eradication, and the effective rate of treatment was 96.7%. Inthe In the second group, there were 24 cases of HP eradication, the eradication rate was 80.0%, 19 cases of gastric polyps disappeared, there were 4 cases of smaller gastric polyps, all appeared in HP eradication, and the effective rate of treatment was 79.7%. There was no significant difference in HP eradication rate between the two groups (χ^2=0.111,P>0.05),the difference in treatment efficiency was statistically significant (χ^2=5.192,P>0.05). The difference of gastrointestinal adverse reactions between the two groups of patients during treatmentwas statistically significant, such as nausea(χ^2=5.934, P=0.015), vomiting (χ^2=19.200, P=0.000), diarrhea, constipation,the difference between the two groups was statistically significant (χ^2=9.017, P=0.003),there was no significant difference in the adverse reactions of between rash and oral mouth odor,the difference between the two groups was statistically significant (χ^2=0.000、P=0.754;χ^2=0.067、P=0.500). Conclusion Gastric hyperplasia polyp is related to HP infection, the combination of the triple live bacterium of Clostridium difficile and the conventional triple regimen for HP treatment of gastric hyperplasia polyp is effective, and can reduce the adverse reaction of gastrointestinal tract.