脑梗死与脑出血早期鉴别的血清标志物概述

Advance in Serum Biomarkers for Early Identification of Cerebral Infarction and Intracerebral Hemorrhage

脑梗死是因局部脑组织血液供应障碍而导致脑组织坏死;脑出血则是因为各种原因导致脑实质内血管破裂出血。虽然二者发病时临床症状有一定相似性,但其发病机制及病理生理过程截然不同,这种差异可能会导致发病早期血清中一些蛋白及基因表达的差异。目前,文献中报道了几种可用于鉴别脑梗死及脑出血的血清标志物,并分析了这些标志物用于脑梗死及脑出血早期鉴别诊断的价值。本文将对这些血清标志物进行综述,希望能够为卒中早期鉴别诊断提供新思路。

Cerebral infarction is caused by cerebrovascular stenosis or occlusion,while intracerebral hemorrhage is caused by cerebrovascular rupture.Although the two kinds of stroke present similar symptoms,their pathogenesis are different,which could lead to different expressions of some proteins and genes at the acute phase of stroke.Recently,some literature reported several serum biomarkers which could differentiate cerebral infarction and cerebral hemorrhage and the early diagnostic value of these biomarkers.This article reviewed the progress of serum biomarkers which could differentiate cerebral infarction and cerebral hemorrhage at the early stage,to provide a reference for early differential diagnosis of stroke.