盐酸氨溴索辅助治疗老年慢性阻塞性肺疾病的临床疗效观察

Clinical Efficacy of Ambroxol Hydrochloride in Elderly Patients with Chronic Obstructive Pulmonary Disease

目的探讨盐酸氨溴索辅助治疗老年慢性阻塞性肺疾病的临床疗效。方法选取某院2015年12月-2017年12月治疗的老年慢性阻塞性肺疾病患者150例,相关患者依据随机数字表法分为常规治疗组和氨溴索辅助治疗组,每组各75例患者。比较2组患者治疗总有效率、临床症状体征评分、肺功能。结果 2组治疗有效率分别为93.33%和77.33%,观察组患者治疗效果更好,差异有统计学意义(P<0.05)。治疗前2组患者临床症状、体征严重程度、FEV1、FVC、PEF等相关指标差异无统计学意义(P>0.05)。治疗后2组患者临床症状体征评分、FEV1、FVC、PEF等指标均有改善,且观察组患者改善更为显著,差异有统计学意义(P<0.05)。结论盐酸氨溴索辅助治疗老年慢性阻塞性肺疾病,可有效缓解症状,改善肺功能,提高治疗效果。

Objectives To explore clinical efficacy of ambroxol hydrochloride in elderly patients with chronic obstructive pulmonary disease. Methods From December 2015 to December 2017, 150 elderly patients with chronic obstructive pulmonary disease(COPD) from Shenzhen Longhua District Central Hospital were randomly divided into control group and observation group. The control group received routine treatment. The observation group was treated with ambroxol hydrochloride on the basis of routine treatment. The total effective rate, clinical symptom score, lung function and safety were compared between the two groups. Results The effective rates of the observation group and the control group were 93.33% and 77.33%, respectively. The observation group was higher than the control group, and the difference was statistically significant(P<0.05). There was no significant difference in clinical symptoms and signs between the two groups before treatment(P>0.05). After treatment, the clinical symptoms and signs of the two groups were improved, the difference was statistically significant(P<0.05). After treatment, the clinical symptoms and signs of patients in the observation group improved more significantly, the difference was statistically significant(P<0.05). Conclusions Ambroxol hydrochloride as an adjuvant therapy for elderly patients with chronic obstructive pulmonary disease could effectively alleviate symptoms, improve pulmonary function and improve therapeutic effect.