基于文献的卒中相关性肺炎中医证候要素组合规律研究

Research on Combination Rule of TMC Syndrome Elements of Stroke-associated Pneumonia based on Literature

目的:通过收集卒中相关性肺炎文献,提取证候要素,探讨卒中相关性肺炎的中医证候要素的分布以及相互组合规律,为卒中相关性肺炎的中医证候要素规律研究提供一定的依据。方法:采用计算机检索和人工检索相结合的方法,对1981年1月-2019年1月卒中相关性肺炎在中医证候方面的相关文献进行收集、整理,应用NoteExpress、SPSS19.0统计软件进行统计。结果:共收集文献30篇、72条记录。影响卒中相关性肺炎辨证的主要证素共有15个,病位因素中以肺为主,病性因素中以痰湿为首。文献记录的卒中相关性肺炎中医证候要素组合形式有3种,两证素最多,构成比59.72%。单一证素与证候位点的组合:证素多见痰湿、气虚,作用位点在肺、脾;两证素组合中,以痰湿的频率最高,其次为火热、气虚、阴虚,其组合类型为痰湿+火热、气虚+阴虚,它们的作用位点在肺和大肠;三证素的证候要素中,以风出现频率最高,组合类型为风+痰湿+火热、风+痰湿+瘀血,作用靶点均在肺。结论:痰湿、火热以及气虚是卒中相关性肺炎的最突出病机特点。

Objectives: To discuss the distribution and combination rule of TCM syndrome elements of stroke-related pneumonia based on literature analysis, so as to provide basis for the research on the distribution rule of TCM syndrome of stroke-related pneumonia. Methods: The related literature of stroke-related pneumonia from January 1981 to January 2019 were collected and sorted by the method of combining computer retrieval and manual retrieval, and the statistics were carried out by using NoteExpress and SPSS 19.0 statistical software. Results: A total of 30 articles and 72 records were collected. Among the 15 syndrome factors, the main syndrome factors that affect the syndrome differentiation of stroke-related pneumonia are mainly lung. Phlegm-dampness is the main disease factor. There are three combinations of TCM syndrome elements of stroke-related pneumonia recorded in the literature, of which two syndrome elements are mainly concentrated, accounting for 59.72%. The combination of single syndrome element and syndrome target: syndrome element is mostly found in phlegm dampness and Qi deficiency, and its action target is located in lung and spleen;In the combination of the two syndrome elements, phlegm-dampness has the highest frequency, followed by fire-heat, Qi deficiency and yin deficiency. The combination type is phleg m-dampness+fire-heat, Qi deficiency+yin deficiency, and their action targets are located in lung and large intestine. Among the syndrome elements of the three syndrome elements, wind has the highest frequency of occurrence, and the combination types are wind + phlegm dampness + heat, wind + phlegm-dampness + blood stasis, and the action targets are all in the lung. Conclusion: Phlegmdampness, heat and Qi deficiency are the main pathogenesis characteristic s of stroke-related pneumonia.