冠心病冠脉病变程度与Apo AI/Apo B、同型半胱氨酸、血脂指标的相关性

Correlation between the degree of coronary artery disease and Apo AI/Apo B, homocysteine and blood lipids

目的探究与分析冠心病冠脉病变程度与载脂蛋白AI/载脂蛋白B(Apo AI/Apo B)、同型半胱氨酸、血脂指标的相关性。方法选取2016年12月~2018年12月辽宁中医药大学附属第二医院(以下简称“我院”)收治的67例经过冠脉造影(CAG)确诊的冠心病患者作为观察组,另选择我院同时期收治的63名健康体检者作为对照组。根据Gensini评分将冠心病患者分为低危组(n = 23)、中危组(n = 22)及高危组(n = 22)。比较各组Apo AI/Apo B、同型半胱氨酸、低密度脂蛋白、胆固醇、三酰甘油水平,探讨冠心病冠脉病变程度与Apo AI/Apo B、同型半胱氨酸、血脂指标的相关性。结果低危组、中危组、高危组的胆固醇、三酰甘油水平比较,差异无统计学意义(P > 0.05)。低危组、中危组、高危组的胆固醇、三酰甘油水平均高于对照组,差异有统计学意义(P < 0.05)。中危组、高危组Apo AI/Apo B低于低危组,但同型半胱氨酸及低密度脂蛋白水平高于低危组,差异有统计学意义(P < 0.05);高危组Apo AI/Apo B低于中危组,但同型半胱氨酸及低密度脂蛋白水平高于中危组,差异有统计学意义(P < 0.05)。低危组、中危组、高危组的同型半胱氨酸及低密度脂蛋白水平均高于对照组,Apo AI/Apo B低于对照组,差异有统计学意义(P < 0.05)。Apo AI/Apo B与冠心病冠脉病变程度呈负相关(r =-0.189,P < 0.05),同型半胱氨酸、低密度脂蛋白冠心病冠脉病变程度呈正相关(r = 0.072~0.095,P < 0.05)。结论 Apo AI/Apo B、同型半胱氨酸与低密度脂蛋白水平与冠心病冠脉病变程度具有一定的相关性,能够用于对疾病的预测及判断。

Objective To investigate and analyze the correlation between the severity of coronary artery disease and apolipoprotein AI/apolipoprotein B (Apo AI/Apo B), homocysteine and blood lipids. Methods From December 2016 to December 2018, 67 patients with coronary heart disease diagnosed by coronary angiography (CAG) admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (“our hospital” for short) were selected as the observation group. A total of 63 healthy medical examiners admitted to our hospital at the same time served as the control group. According to the Gensini score, patients with coronary heart disease were divided into low-risk group (n = 23), intermediate-risk group (n = 22) and high-risk group (n = 22). The levels of Apo AI/Apo B, homocysteine, low density lipoprotein, cholesterol and triglyceride in each group were compared to explore the correlation between the severity of coronary artery disease and the indexes of Apo AI/Apo B, homocysteine and blood lipids. Results There were no significant differences in cholesterol and triglyceride levels between the low-risk group, the intermediate-risk group and the high-risk group (P > 0.05). The levels of cholesterol and triglyceride in the low-risk group, the intermediate-risk group and the high-risk group were higher than those in the control group, the differences were statistically significant (P < 0.05). The Apo AI/Apo B in the intermediate-risk group and the high-risk group were lower than the low-risk group, but the homocysteine and low-density lipoprotein levels were higher than the low-risk group, the differences were statistically significant (P < 0.05);Apo AI /Apo B in the high-risk group was lower than the intermediate-risk group, but homocysteine and low density lipoprotein levels were higher than the intermediate-risk group, the differences were statistically significant (P < 0.05). The levels of homocysteine and low density lipoprotein in the low-risk group, the intermediate-risk group and the high-risk group were higher than those in the control group, and the Apo AI/Apo B was lower than that in the control group, the differences were statistically significant (P < 0.05). Apo AI/Apo B was negatively correlated with coronary artery disease (r =-0.189, P < 0.05), and positively correlated with homocysteine and low-density lipoprotein coronary heart disease (r = 0.072-0.095, P < 0.05). Conclusion Apo AI/Apo B, homocysteine and low density lipoprotein levels are correlated with the severity of coronary artery disease, which can be used to predict and judge the disease.