经腹超声引导聚桂醇联合射频消融治疗对子宫肌瘤患者淋巴细胞及血清因子水平的影响

Effects of Transabdominal Ultrasound Guided Lauromacrogol Combined with Radiofrequency Ablation on the Levels of Immune Lymphocytes and E2,LH and FSH in Serum of Patients with Hysteromyoma

目的研究在子宫肌瘤治疗中采用经腹超声引导聚桂醇联合射频消融射频治疗对患者免疫淋巴细胞及血清E2、LH、FSH水平的影响。方法选取2014~2017年在笔者医院接诊的子宫肌瘤患者82例,根据手术类型分为对照组38例和观察组44例。对照组采用经腹超声引导射频消融术进行治疗,观察组采用经腹超声引导聚桂醇联合射频消融射频治疗。采用流式细胞术检测两组患者手术前后免疫淋巴细胞水平、血清E2、LH、FSH的水平,进行对比分析。术后定期复查,掌握病情发展。结果观察组有效率95.5%优于对照组76.3%,术后观察组和对照组肌瘤缩小程度分别为95.5%、78.9%,观察组比对照组缩小明显(P<0.05)。免疫淋巴细胞(CD3^+、CD4^+、CD8^+)水平手术前比较,差异无统计学意义,术后两组免疫淋巴细胞CD3^+、CD4^+水平较治疗前均显著升高,CD8^+水平降低且观察组同对照组比较,差异无统计学意义。血清E2、LH、FSH的水平在治疗前比较,差异无统计学意义,治疗后两组均明显下降(P<0.05),且观察组同对照组比较,差异无统计学意义。结论经腹超声引导聚桂醇联合射频消融射频治疗子宫肌瘤效果明显,能显著提高免疫淋巴细胞水平,降低血清E2、LH、FSH的水平,且长期疗效较单纯射频消融术好。

Objective To study the effect of transabdominal ultrasoundguided lauromacrogol combined with radiofrequency ablation on the levels of immune lymphocytes and E2,LH and FSH in patients with uterine fibroids.Methods Eighty-two cases of uterine fibroids were selected in our hospital from 2014 to 2017 years.38 cases were divided into the control group and 44 cases in the observation group according to the type of operation.The control group was treated by transabdominal ultrasound guided radiofrequency ablation,while the observation group was treated by transabdominal ultrasound guided lauromacrogol combined with radiofrequency ablation.Flow cytometry was used to detect the level of immune lymphocyte and E2,LH,FSH in serum before and after operation in two groups.Periodic review after operation to master the development of the disease.Results The efficiency of the observation group is 95.5%which is better than the control group with 76.3%,and The degree of myoma reduction in the observation group and the control group was 95.5% and 78.9%,and myoma reduction of the observation group was more than control group ( P <0.05).There was no difference in immune lymphocyte (CD3^+,CD4^+,CD8^+) before operation.After operation,the lymphocyte level of CD3^+,CD4^+ in the two groups increased significantly compared with that before treatment and level of CD8^+ decreased ( P <0.05),and there was no difference between the observation group and the control group.There was no difference in serum E2,LH,FSH before treatment.After treatment,the indicators in the two groups decreased significantly ( P <0.05),and there was no difference between the observation group and the control group.Conclusion Transabdominal ultrasound guided poly (cinnamyl alcohol) combined with radiofrequency ablation for uterine leiomyoma has obvious effect,can significantly improve the level of immune lymphocyte,reduce the level of serum E2,LH,FSH.The long-term effect is better than radiofrequency ablation alone.