芪明颗粒联合小牛血去蛋白提取物眼用凝胶治疗糖尿病超乳术后干眼症

Qiming Granules combined with Deproteinized Calfblood Extract Eye Gel in the treatment of diabetes phaeoemulsification postoperative xerophthalmia

目的:观察芪明颗粒联合小牛血去蛋白提取物眼用凝胶对糖尿病超声乳化术后干眼症患者的疗效。方法:收集2017-06/2018-06于我院进行白内障超声乳化术后患干眼症的2型糖尿病患者147例269眼。根据治疗方法不同分为对照组(妥布霉素地塞米松滴眼液联合双氯芬酸钠滴眼液),小牛血去蛋白提取物眼用凝胶组(在对照组用药基础上加用小牛血去蛋白提取物眼用凝胶),联合组(在小牛血去蛋白提取物眼用凝胶组用药基础上加用芪明颗粒)。三组疗程均为4wk。观察治疗后1mo患者FL、BUT及SⅠt情况,并分析各组临床疗效。结果:治疗前,三组患者BUT及SⅠt均无差异(P>0.05);治疗后1mo,小牛血去蛋白提取物眼用凝胶组和联合组BUT及SⅠt均较对照组改善,且联合组较小牛血去蛋白提取物眼用凝胶组提高更为明显(P<0.05)。此外,联合组总有效率高于小牛血去蛋白提取物眼用凝胶组(97.9%vs 89.0%,P=0.013)。结论:芪明颗粒联合小牛血去蛋白提取物治疗糖尿病患者超声乳化术后干眼症的疗效明显,能改善患者自觉症状,提高眼部舒适度及生活质量。

AIM:To retrospectively analyze the effect of Qiming Granules combined with Deproteinized Calfblood Extract Eye Gel in the treatment of diabetes phaeoemulsification postoperative xerophthalmia. METHODS:From June 2017 to June 2018, 147 diabetics 269 eyes were diagnosed with phaeoemulsification postoperative xerophthalmia were enrolled in our study. The control group was given the Tobramycin Dexamethasone Eye Drops and Diclofenac Sodium Eye Drops, the Sugaojie group was given Deproteinized Calfblood Extract Eye Gel on the basic of the control group, the combined group was given the Qiming Granules on the basic of the Sugaojie group. The courses all last 4wk. The corneal fluorescence staining, BUT and SⅠt were analyzed before, and post 1mo after treatment, and the clinical efficacy of each group was analyzed. RESULTS: There was no difference among three groups on BUT and SⅠt before treatment( P >0.05). After 1 mo treatment, BUT and SⅠt of the Sugaojie group and the combined group were significantly improved compared to the control group( P <0.05), furthermore, the combined group did better role on BUT, SⅠt and total effective rate compared to the Sugaojie group(97.9% vs 89.0%, P =0.013). CONCLUSION: Qiming Granules combined with Deproteinized Calf blood Extract Eye Gel could improve xerophthalmia after phaeoemulsification surgery. It is a positive and effective treatment, which has good clinical application significance.