立体定向放疗治疗原发性肝癌的疗效分析

Effect analysis of stereotactic radiotherapy on primary liver carcinoma

目的:探讨立体定向放疗治疗原发性肝癌的疗效、安全性及对患者生存率的影响。方法:选取56例原发性肝癌患者作为观察对象,按照随机数字表法分为对照组25例和研究组31例,对照组行单纯肝动脉栓塞化疗术,研究组在对照组基础上给予立体定向放疗,对比两组疗效、不良反应发生率、生存率。结果:研究组总有效率为80.6%,高于对照组的36.0%,差异有统计学意义(P<0.05);治疗后两组血清肝癌标志物甲胎蛋白异质体(AFP-L3)、组织蛋白酶S(CatS)、高尔基体蛋白73(GP73)均下降,其中研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05);研究组0.5年、1年、2年生存率分别为77.4%、51.6%、35.4%,均高于对照组的52.0%、20.0%、8.0%,差异有统计学意义(P<0.05)。结论:立体定向放疗治疗原发性肝癌能够提高疗效,提高患者生存率,且不会明显增加不良反应。

Objective:To investigate efficacy and safety of stereotactic radiotherapy in the treatment of primary hepatocellular carcinoma (HPC),and to analyze its effects on the survival rate.Methods:56 patients were selected as the observation subjects.According to the random number table method,they were divided into control group (n=25) and study group (n=31).The control group underwent simple transcatheter arterial chemoembolization,while the study group was given stereotactic radiotherapy on the basis of that of the control group. The efficacy,adverse reaction rate and survival rate of the two groups were compared.Results:The total effective rate of the study group was 80.6%,which was higher than that of the control group (36.0%)(P<0.05).The serum AFP-L3,Cat S and GP73 levels decreased after that treatment,and those of the study group were lower than those of the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).The 5-year,1-year,and 2-year survival rates of the study group were 77.4%, 51.6%,and 35.4%,separately,which were higher than the control group of 52.0%.20.0%,and 8.0%,and the differences were statistically significant (P<0.05).Conclusions:Stereotactic radiotherapy in the treatment of HPC can improve the efficacy and improve the survival rate of the patients without significantly increasing the adverse reacti ons.