替诺福韦治疗慢性乙型肝炎病毒感染进展

New Progress of Tenofovir in Treatment of Chronic Hepatitis B Virus Infection

替诺福韦是一种新型的核苷类似物,此文章介绍替诺福韦的药学特性、作用机制、适应症、用法、治疗效果以及安全性等方面的新进展。替诺福韦被认为有很强的抑制乙肝病毒复制的作用,可广泛应用于慢性乙肝初治治疗及耐药挽救治疗、肝硬化、母婴传播阻断治疗等,而且耐药率低,安全性好。是目前治疗慢性乙肝病毒感染的一线药物之一。

Tenofovir is a new kind of nucleoside analogue.This article reviews the new progress about the pharmaceutical characteristics, mechanisms, indications, uses, therapeutic effects and safety of tenofovir. It is considered tenofovir may strongly inhibit hepatitis B virus replication,It can be widely used for the treatment of chronic hepatitis B, rescue therapy for drug resistance, liver cirrhosis, mother to child transmission interruption therapy and so on, and it has low resistance rate and high safety. It is one of the first-line drugs for the treatment of chronic hepatitis B virus infection.