平阳霉素联合聚桂醇治疗口腔颌面部血管瘤的临床效果研究

Clinical Effect of Pingyangmycin Combined with Polyglycerol in the Treatment of Oral and Maxillofacial Hemangioma

目的探讨平阳霉素联合聚桂醇治疗口腔颌面部血管瘤的临床效果进行研究。方法选择2018年1—12月在该院诊疗的50例口腔颌面部血管瘤患者作为该次研究的一般对象,并采取随机的方式将其均分为对照组及观察组,各25例。两组均实施常规检查,对照组采用平阳霉素治疗,观察组在对照组治疗方案的基础上联合聚桂醇治疗,对比两组临床疗效、瘤体面积和厚度以及不良反应发生情况。结果观察组治疗后的总体有效率、不良反应发生率分别为96.00%、8.00%,对照组的总体有效率及不良反应发生率为76.00%、28.00%,观察组优于对照组,两组差异有统计学意义(χ^2=12.9418、12.7841,P<0.05);观察组治疗后瘤体面积及厚度分别为(3.91±0.58)cm2、(3.46±0.52)mm,对照组治疗后瘤体面积及厚度分别为(7.14±1.02)cm2、(5.87±0.69)mm。观察组治疗后的瘤体面积及厚度均小于对照组,两组差异有统计学意义(t=4.9127、4.8413,P<0.05)。结论口腔颌面部血管瘤通过平阳霉素联合聚桂醇治疗可提升临床疗效,并使临床症状得以有效改善,且不良反应较少,具有一定的安全性,值得推广。

Objective To investigate the clinical effects of pingyangmycin combined with polyglycerol in the treatment of oral and maxillofacial hemangioma. Methods A total of 50 patients with oral and maxillofacial hemangioma who were treated in our hospital from January to December 2018 were selected as the general subjects of the study. They were randomly divided into control group and observation group. 25 cases each. Routine examinations were performed in both groups. The control group was treated with pingyangmycin. The observation group was treated with polyglycerol on the basis of the treatment plan of the control group. The clinical efficacy, tumor area and thickness, and adverse reactions were compared between the two groups. Results The overall effective rate and adverse reaction rate of the observation group were 96.00% and 8.00%, respectively. The overall effective rate and adverse reaction rate of the control group were 76.00% and 28.00%. The observation group was superior to the control group. The dominant difference was statistically significant(χ^2=12.941 8, 12.784 1,P<0.05. The tumor area and thickness of the observation group were (3.91±0.58) cm2,(3.46±0.52) mm, respectively. The area and thickness were (7.14±1.02) cm2 and (5.87±0.69) mm, respectively. The area and thickness of the tumor in the observation group were smaller than those in the control group. There were significant differences between the two groups, with statistical significance(t=4.912 7, 4.841 3,P<0.05). Conclusion The treatment of oral and maxillofacial hemangioma with pingyangmycin combined with polyglycerol can improve the clinical efficacy, improve the clinical symptoms, and have fewer adverse reactions. It has certain safety and is worthy of promotion.