抗环瓜氨酸肽抗体与抗角蛋白抗体检测在类风湿关节炎诊断中的应用价值

Application values of anti-cyclic citrullinated peptide antibody and anti-keratin antibody detections in the diagnosis of rheumatoid arthritis

目的探讨抗环瓜氨酸肽抗体(抗CCP抗体)与抗角蛋白抗体(AKA)检测在类风湿关节炎(RA)诊断中的应用价值.方法选取64例RA患者为A组,同期64例非RA患者为B组,同期64名健康体检者为C组.3组均采用抗CCP抗体与AKA检测法,比较3组检测结果.结果在特异性方面,抗CCP抗体检测与AKA检测结果有显著差异(P<0.05);在灵敏度方面,抗CCP抗体检测与AKA检测结果无显著差异(P>0.05);联合检测结果方面,特异性与灵敏度均较单独的抗CCP抗体检测、AKA检测有显著差异(P<0.05);在阳性预测值上,抗CCP抗体检测显著更高(P<0.05);在阴性预测值上,联合检测显著较高(P<0.05).结论随着实验操作技术的发展,多项指标联合检测将会在RA的诊断中得到推广与应用,进一步提高诊断的准确性.

Objective To explore the application values of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) and anti-keratin antibody (AKA) detections in the diagnosis of rheumatoid arthritis (RA). Methods Totally 64 patients with RA were selected as group A, 64 patients without RA were selected as group B, and 64 healthy people were selected as group C. Anti-CCP antibody and AKA detections were performed in all the three groups, and the results were compared. Results In terms of specificity, there was a significant difference between anti-CCP antibody detection and AKA detection ( P <0.05). In terms of sensitivity, there was no significant difference between anti-CCP antibody detection and AKA detection ( P >0.05). The specificity and sensitity of combined detection showed a significant difference compared to anti-CCP antibody detection or AKA detection alone ( P <0.05). Anti-CCP antibody detection was significantly higher in positive predictive value ( P <0.05), and combined detection was significantly higher in negative predictive value ( P <0.05). Conclusion With the development of experimental operation technology, the combined detection of multiple indicators will be popularized and applied in the diagnosis of RA, and the accuracy of diagnosis will be further improved.