摘要
有机碘化合物在有机合成中具有重要作用,可用于碳-碳键和碳-杂原子键的形成反应中,发展有机碘化物的高效制备尤为重要.报道了一种利用廉价、安全和易得的硼氢化钠和碘单质在1,4-二氧六环中将醇类化合物转化为对应碘化物的反应.该方法对于苄醇类化合物和烷基醇类化合物十分有效,而烯丙基类醇和二级三级醇则不反应.
A simple,mild,and high yielding procedure for the iodination of alcohols using a combination of NaBH4 and I2 is described.The effectiveness of the protocol is achieved with benzylic alcohols and primary alkylic alcohols whereas allylic and secondary alcohols are found to be unreactive.
作者
樊正宁
张博
席婵娟
Fan Zhengning;Zhang Bo;Xi Chanjuan(Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084;State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第8期2333-2337,共5页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(Nos.21871163,91645120)~~
关键词
醇
碘化物
硼氢化钠
碘化
alcohol
iodide
sodium borohydride
iodination
