甲胎蛋白、胸苷激酶1、Dickkopf相关蛋白1联合检测在原发性肝癌中的诊断价值

Diagnostic value of combined detection of serum α-fetoprotein, thymidine kinase 1and dickkopf WNT signaling pathway inhibitor 1 in primary liver cancer

目的探讨血清甲胎蛋白(AFP)、胸苷激酶1(TK1)、Dickkopf相关蛋白1(DKK1)联合检测在原发性肝癌中的诊断价值。方法选取120例原发性肝癌患者(原发性肝癌组)、90例良性肝病患者(良性肝病组)和80例健康体检者(健康对照组)作为研究对象,比较3组受试者血清中AFP、TK1、DKK1的水平及阳性表达情况,计算AFP、TK1、DKK1单独及联合检测诊断原发性肝癌的灵敏度、特异度和准确度。结果原发性肝癌组患者血清中AFP、TK1和DKK1的水平均高于良性肝病组和健康对照组(P﹤0.05)。原发性肝癌组患者血清中AFP、TK1和DKK1的阳性表达率均高于良性肝病组和健康对照组(P﹤0.05)。AFP、TK1、DKK1联合检测诊断原发性肝癌的灵敏度、特异度和准确度均高于AFP、TK1、DKK1单独检测的结果。结论血清AFP、TK1、DKK1联合检测对原发性肝癌的诊断具有较高的灵敏度、特异度和准确度,对于临床原发性肝癌的诊断具有重要的参考价值,值得临床推广和应用。

Objective To investigate the diagnostic value of combined detection of serumα-fetoprotein(AFP),thymidine kinase 1(TK1)and dickkopf WNT signaling pathway inhibitor 1(DKK1)in primary liver cancer.Method One hundred and twenty patients with primary liver cancer were included as the primary liver cancer group,another 90 patients with benign liver disease and 80 healthy subjects were included as benign liver disease group and healthy control group,respectively,the levels of AFP,TK1 and DKK1 in the serum of subjects in the three groups were detected and compared,and the sensitivity,specificity and accuracy of AFP,TK1 and DKK1 applied alone or in combination in detecting primary liver cancer were investigated.Result The level and positive rate of AFP,TK1 and DKK1 in the serum of patients with primary liver cancer were higher than those in patients with benign liver disease group and healthy control group(P<0.05).When combined,the sensitivity,specificity and accuracy of AFP,TK1 and DKK1 were higher than that of AFP,TK1 and DKK1 applied alone.Conclusion The combined detection of serum AFP,TK1,and DKK1 are highly sensitive,specificity and accurate in the diagnosis of primary liver cancer,demonstrating the important diagnostic value.