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胸腺损伤与猪蓝耳病防控

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摘要 猪繁殖与呼吸综合征(PRRS)又称猪蓝耳病,它主要引起母猪繁殖障碍和生长育肥猪的呼吸道疾病,是一种严重危害全球养猪业的重要疫病.目前国内流行的猪蓝耳病毒株主要为PRRSV-2型(北美型),在我国又分为经典毒株和高致病性毒株,近年来又出现了类NADC-30毒株.猪蓝耳病病毒感染猪群之后,会引起严重的免疫抑制,特别是高致病性毒株感染后,会严重破坏仔猪中枢免疫器官——胸腺,导致骨髓干细胞流经胸腺时,不能正常分化、发育为成熟的CD4+和CD8+ T细胞,从而抑制了细胞免疫和体液免疫,最终对各种疫苗免疫难以产生免疫应答,所以临床上表现为猪蓝耳病病毒感染后免疫猪瘟、猪蓝耳病、猪伪狂犬病等疫苗效果不理想,并导致多种疫病混合感染.
出处 《猪业科学》 2019年第8期92-93,共2页 Swine Industry Science
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