子宫内膜异位症患者血清CA125、HE4、EMAb的表达及其临床意义

Serum CA125, HE4 and EMAb Expression in Patients with Endometriosis and Their Clinical Significance

目的探究子宫内膜异位症患者血清CA125、HE4、EMAb情况及临床意义。方法选择68例该院疑似子宫内膜异位症患者,纳入时间为2017年1月-2018年1月,均对其实施血清CA125、HE4、EMAb检验,统计不同检验诊断准确性,对比血清CA125、HE4、EMAb水平。结果疑似子宫内膜异位症患者确诊结果阳性51例(75.00%)、阴性17例(25.00%);CA125检验阳性47例(69.12%)、阴性21例(30.88%);HE4检验阳性48例(70.59%)、阴性20例(29.41%);EMAb检验阳性46例(67.65%)、阴性22例(32.35%);联合检验阳性50例(73.53%)、阴性18例(26.47%);疑似子宫内膜异位症联合检验诊断结果灵敏度、特异度、准确性均明显高于CA125检验、HE4检验、EMAb检验,联合检验与CA125检验的检验值:(χ2=10.930 9、12.142 9、21.166 2,P=0.0009、0.000 4、0.000 0);联合检验与HE4检验的检验值:(χ2=8.541 2、10.087 9、17.106 9,P=0.003 4、0.001 4、0.000 0);联合检验与EMAb检验的检验值:(χ2=9.714 3、8.242 4、17.106 9,P=0.001 8、0.004 0、0.000 0)。子宫内膜异位症患者CA125、HE4、EMAb水平明显高于非子宫内膜异位症患者,组间差异有统计学意义(t=24.864 8、16.326 4、14.530 9, P=0.000 0、0.000 0、0.000 0 <0.05)。结论子宫内膜异位症患者血清CA125、HE4、EMAb水平较高,通过对患者实施血清CA125、HE4、EMAb检验能够对其诊断,为临床诊断提供参考,应予以临床推广。

Objective To investigate the serum CA125, HE4 and EMAb in patients with endometriosis and their clinical significance. Methods A total of 68 patients with suspected endometriosis in our hospital from January 2017 to January 2018 were selected, and their serum CA125, HE4 and EMAb tests were performed. The diagnostic accuracy of different tests were counted, and serum CA125, HE4 and EMAb levels were compared. Results The 51 cases(75.00%) were positive and 17 cases(25.00%) were negative. CA125 was positive in 47 cases(69.12%) and negative in 21 cases(30.88%). There were 48 positive cases(70.59%) and 20 negative cases(29.41%) of HE4 test. There were46(67.65%) positive cases and 22(32.35%) negative cases. And 50 cases(73.53%) were positive and 18 cases(26.47%) were negative in the combined test. The sensitivity, specificity and accuracy of the combined test of suspected endometriosis were significantly higher than those of CA125 test, HE4 test and EMAb test. The test values of combined test and CA125 test:χ2=10.930 9, 12.142 9, 21.166 2, P=0.000 9, 0.000 4, 0.000 0. Test values of combined test and HE4 test:χ2=8.541 2, 10.087 9, 17.106 9, P=0.003 4, 0.0014, 0.000 0. The test values of combined test and EMAb test:χ2=9.714 3, 8.242 4, 17.106 9, P=0.001 8, 0.004 0, 0.000 0. The levels of CA125, HE4 and EMAb in patients with endometriosis were significantly higher than those in patients without endometriosis, and the difference between the two groups was statistically significant(t=24.864 8, 16.326 4, 14.530 9, P=0.000 0、0.000 0、0.000 0 <0.05).Conclusion Serum CA125, HE4, and EMAb levels in patients with endometriosis are relatively high. The diagnosis of patients with endometriosis by serum CA125, HE4, and EMAb tests can provide a reference for clinical diagnosis and should be promoted clinically.