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益心舒片的HPLC-ELSD指纹图谱研究

Study on HPLC-ELSD Finger-print of Yixinshu Tablets
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摘要 目的:建立益心舒片的高效液相-蒸发光散射指纹图谱.方法:采用Agilent ZORBAX Eclipse XDB C18柱,以甲醇-乙腈为流动相,梯度洗脱,流速1.0mL·min^-1,柱温25℃;蒸发光散射检测器:漂移管温度105℃,载气N2,载气流速2.5mL·min^-1.结果:10批益心舒片指纹图谱中有12个共有峰,各峰分离度良好,样品间相似度均>90%.结论:本方法具有良好的精密度、重现性、稳定性,分离度高. Objective: To establish a HPLC-ELSD finger-print of Yixinshu tablets.Methods: Agilent ZORBAX Eclipse XDB C1S column was used with methanol-acetonitrile as mobile phase,gradient elution,flow rate of 1.0 mL·min^-1,and column temperature 25℃.Evaporative light scattering detector: drift tube temperature 105℃,carrier gas carrier gas flow rate 2.5 mL·min^-1.Results: There were 12 common peaks in thefinger-prints of 10 batches of Yixinshu tablets.The separation degree of each peak was good,and the similarity among samples was > 90%.Conclusion: The method has good precision,reproducibility,stability and high separation.
作者 胡晗绯 于桂芳 付娟 胡军华 王振中 Hu Hanfei;Yu Guifang;Fu Juan;Hu Junhua;Wang Zhenzhong(Jiangsu Kangyuan Pharmaceutical CO.,LTD.,Jiangsu,222001;New Technology State Key Laboratory of Pharmaceutical Process of Traditional Chinese Medicine,Jiangsu,222001)
出处 《当代化工研究》 2019年第10期191-192,共2页 Modern Chemical Research
基金 科技部重大新药创制(2013ZX09402203)
关键词 益心舒片 HPLC-ELSD 指纹图谱 Yixinshu tablet HPLC-ELSD finger-print
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