微生态制剂在结肠癌合并不全性肠梗阻治疗中的应用效果及预后影响分析

Effect of microecological preparation in the treatment of colon cancer complicated with incomplete intestinal obstruction and its prognostic effect

目的探讨微生态制剂在结肠癌合并不全性肠梗阻患者中的应用效果及其对患者预后的影响。方法选取2016年3月至2018年2月本院收治的96例结肠癌合并不全性肠梗阻患者为研究对象,采用随机数表法将其分为观察组(48例)和对照组(48例),观察组患者在常规治疗基础上接受微生态制剂治疗,对照组患者接受常规治疗,比较两组患者治疗前后的营养状况、手术情况、预后情况和生存质量。结果观察组患者血红蛋白、白蛋白、CD3+CD8+T细胞水平和体重均显著高于对照组(均P<0.05),术后排气时间和首次排便时间均显著短于对照组(均P<0.05),总体健康、躯体功能、情绪功能、认知功能、社会功能、疲倦、恶心呕吐、食欲减退、便秘、腹泻评分均显著低于对照组(均P<0.05)。结论在术后常规治疗基础上增加微生态制剂可以改善结肠癌合并不全肠梗阻患者营养状况,缩短术后排气和首次排便时间,提高患者免疫功能和生活质量,值得临床推广。

Objective To investigate the effect of microecological preparation on the prognosis of patients with colon cancer complicated with incomplete intestinal obstruction. Method From March 2016 to February 2018, 96 patients with colon cancer complicated with incomplete intestinal obstruction were selected as the subjects. All patients were randomly divided into observation group (n = 48) and control group (n = 48). The patients in observation group were treated with microecological agents on the basis of routine treatment, patients in control group received routine treatment. The nutritional status, surgical status, prognosis and quality of life of the two groups before and after treatment were compared. Result The levels of hemoglobin, albumin, CD3+CD8+ T cells body weight in observation group were significantly higher than those in control group (all P < 0.05). The postoperative exhaust time and the first defecation time in observation group were significantly shorter than those in control group (all P < 0.05). The scores of overall health, physical function, and emotional function, cognitive function, social function, fatigue, nausea and vomiting, anorexia, constipation, and diarrhea in observation group were significantly lower than those in control group (all P < 0.05). Conclusion The addition of microecological preparation on the basis of routine treatment in patients with colon cancer complicated with incomplete intestinal obstruction can improve the nutritional status of patients, shorten the postoperative exhaust and first defecation time, and improve the immune function and quality of life of patients, which is worthy of clinical promotion.