阿司匹林联合他汀类治疗脑血栓患者临床疗效及对神经功能的影响

Clinical efficacy and effective effect of aspirin combined with statins in the treatment of patients with cerebral thrombosis

目的观察并研究将阿司匹林与他汀类药物联合运用在脑血栓患者治疗中的临床疗效和对神经功能的影响。方法本研究选取2016年4月至2018年6月本院纳入治疗的80例脑血栓患者,依据患者住院日期单双号实行分组,每组40例。常规治疗应用于两组,对照组增加阿司匹林治疗方案,实验组增加阿司匹林与他汀类药物联合治疗方案,评估两组治疗前和治疗2周后的颈动脉斑块面积、神经功能缺损评分分数,并计算两组临床有效率。结果实验组治疗2周后的颈动脉斑块面积较治疗前、对照组指标均显著更小,差异有统计学意义(P<0.05);实验组临床有效率较对照组指标更高,差异有统计学意义(P<0.05);实验组治疗2周后的神经功能缺损评分分数较治疗前、治疗后对照组指标均显著更小,差异有统计学意义(P<0.05)。结论对脑血栓患者采取阿司匹林与他汀类药物联合治疗方案展示较优效果,呈现治疗优势。

Objective To observe and study the clinical efficacy and neurological function of aspirin combined with statins in the treatment of patients with cerebral thrombosis.Methods 80 patients with cerebral thrombosis who were included in the hospital from April 2016 to June 2018.According to the patient's hospitalization date,They were divided into two groups,with 40 cases in each group.In the two groups,the control group increased the aspirin treatment plan,the experimental group increased the combination of aspirin and statin treatment,evaluated the carotid plaque area and neurological deficit scores before and after 2 weeks of treatment,and calculated clinical effective rate of the two groups.Results The area of carotid plaques in the experimental group was significantly smaller than that in the control group and the control group after 2 weeks of treatment,showing statistical significance(P<0.05).The clinical effective rate of the experimental group was higher than that of the control group,the statistical significance of the values(P<0.05).The scores of neurological deficits in the experimental group after 2 weeks of treatment were significantly smaller than those before and after treatment of the control group,showing statistical significance(P<0.05).Conclusion The combination of aspirin and statin in patients with cerebral thrombosis shows superior effects and presents therapeutic advantages.