支气管热成形术患者免疫功能变化的研究

Study on the changes of immune function in patients with bronchial thermoplasty

目的分析讨论对重症持续性支气管哮喘患者使用支气管热成形术的具体价值和实际效果。方法回顾性分析本院2016年1月-2017年12月重症持续性支气管哮喘患者17例,对所有患者进行支气管热成形术,比较治疗前后哮喘控制(ACT)评分、嗜酸粒细胞、白介素-4(IL-4)、白介素-5(IL-5)、白介素-13(IL-13)和总有效率。结果治疗前,ACT评分为(8.14±2.03)分,治疗后,ACT评分为(19.65±2.73)分,治疗后ACT评分明显高于治疗前,差异具有统计学意义(t=14.475,P<0.05)。治疗后嗜酸粒细胞和IL-4水平明显低于治疗前,P<0.05。治疗后IL-5和IL-13水平明显低于治疗前,P<0.05。治疗后,显效患者5例,有效患者11例,无效患者1例,总有效率为94.12%(16/17)。结论对重症持续性支气管哮喘患者使用支气管热成形术可以降低炎症因子水平,缓解症状,整体治疗效果较好,可在临床治疗中推广使用。

Objective To analyze and discuss the specific value and practical effect of bronchial thermoplasty for severe persistent bronchial asthma patients.Methods 17 patients with severe persistent bronchial asthma from January 2016 to December 2017 were retrospectively analyzed.All patients underwent bronchial thermoplasty.The scores of asthma control(ACT),eosinophils,interleukin-4(IL-4),interleukin-5(IL-5),interleukin-13(IL-13)and total effective rate were compared before and after treatment.Results Before treatment,ACT score was(8.14±2.03)points,and after treatment,ACT score was(19.65±2.73)points.ACT score was significantly higher after than before treatment(t=14.475,P<0.05).After treatment,the levels of eosinophils and IL-4 were significantly lower than those before treatment(P<0.05),and the levels of IL-5 and IL-13 were significantly lower than those before treatment(P<0.05).After treatment,there were 5 markedly effective patients,11 effective patients and 1 ineffective patient,and the total effective rate was 94.12%(16/17).Conclusion Bronchial thermoplasty can significantly reduce the levels of inflammatory cytokines and relieve symptoms in patients with severe persistent bronchial asthma.The overall therapeutic effect is good and it can be widely used in clinical treatment.