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原发性肺淋巴上皮瘤样癌的临床诊治进展 被引量:2

Clinical research progress of primary pulmonary lymphoepithelioma-like carcinoma
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摘要 原发性肺淋巴上皮瘤样癌是一类少见的肺恶性肿瘤。EB病毒(Epstein-Barr virus,EBV)感染可能与其发病有密切联系,其发病呈现显著的地域特征,发病对象多以年轻、不吸烟患者为主。其临床表现无特异性,多数患者在确诊时没有临床症状。手术切除为早期原发性肺淋巴上皮瘤样癌的主要治疗手段;以铂为基础的双药联合化疗作为晚期淋巴上皮瘤样癌的一线治疗方案,但目前仍然缺少大样本随机对照试验证实其为最佳治疗方案;对于靶向治疗、免疫治疗的临床治疗效果还有待进一步的深入研究。本文综述了原发性肺淋巴上皮瘤样癌的诊治研究现状,以期为临床医师提供参考,为研究者深入研究该类少见类型癌症提供方向。 Primary pulmonary lymphoepithelioma-like carcinoma(PPLELC)is a rare type of lung cancer with special characteristics of epidemiology,clinical diagnosis,treatment and prognosis.It has close relationship with Epstein-Barr virus(EBV)infection and has prominent regional feature.Most patients are young and non-smoking.There is no specificity of clinical manifestation.Most patients are asymptomatic at the time of diagnosis.As for treatment,the standard treatment for early stage disease is complete resection.Platinum-based doublet chemotherapy has been applied in locally advanced disease as the first line therapy.Due to its rarity,the treatment of advanced PPLELC is still lack of evidence of large sample randomized controlled trial.Whether target therapy or immunotherapy is effective is worth further study.This article reviews the research progress of PPLELC,to give a particular sight for clinicians and provides a better understanding of this rare tumor for researchers.
作者 张锦珏 陈楠 周健 林锋 ZHANG Jinjue;CHEN Nan;ZHOUJian;LIN Feng(West China Medical School,Sichuan University,Chengdu,610041,P.R.China;Department of Thoracic Surgery,West China Hospital,Sichuan University,Chengdu,610041,P.R.China)
出处 《中国胸心血管外科临床杂志》 CAS CSCD 2019年第11期1141-1144,共4页 Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词 肺淋巴上皮瘤样癌 EB病毒 诊断 治疗 研究进展 Pulmonary lymphoepithelioma-like carcinoma Epstein-Barr virus diagnosis treatment research progress
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