血清LP-PLA2与冠心病患者冠脉病变程度及血管内皮指标的关系

Relationship between serum LP-PLA2 and degree of coronary artery lesion and vascular endothelial indexes in patients with coronary heart disease

目的探究血清脂蛋白相关磷脂酶A2(LP-PLA2)与冠心病患者冠脉病变程度及血管内皮指标的关系。方法选取陕西省第二人民医院2017年2月至2019年1月期间的90例冠心病患者为观察组,同时期的90例体检健康者为对照组。比较两组受检者的血清LP-PLA2及血管内皮指标,同时比较观察组中不同分型及Gensini积分患者的血清LP-PLA2及血管内皮指标[内皮素-1(ET-1)、可溶性血管细胞黏附分子-1(sVCAM-1)、可溶性细胞间黏附分子-1(sICAM-1)、血管性血友病因子(vWF)],采用Pearson相关性分析血清LP-PLA2与Gensini积分、血管内皮指标的关系。结果观察组患者的血清LP-PLA2、ET-1、sVCAM-1、sICAM-1及vWF分别为(275.65±28.96)pg/mL、(28.98±5.12)ng/L、(223.63±25.68)g/L、(663.75±78.65)g/L及(120.35±18.96)U/L,均明显高于对照组的(122.32±18.96)pg/mL、(6.12±1.35)ng/L、(110.61±16.75)g/L、(320.17±28.96)g/L及(68.21±8.38)U/L,差异均有统计学意义(P<0.05);观察组患者中不同分型及Gensini积分患者的血清LP-PLA2及血管内皮指标比较,差异也均有统计学意义(P<0.05);Pearson相关性分析结果显示,血清LP-PLA2与Gensini积分、血管内皮指标均呈正相关(r=0.756、0.812、0.903、0.887、0.796,P<0.05)。结论血清LP-PLA2与冠心病患者冠脉病变程度及血管内皮指标均有密切的关系,在冠心病患者中具有较高的检测价值。

Objective To investigate the relationship between serum lipoprotein-associated phospholipase A2(LP-PLA2)and degree of coronary artery lesion and vascular endothelial indexes in patients with coronary heart disease.Methods From February 2017 to January 2019,90 patients with coronary heart disease treated in the Shaanxi Provincial Geriatric Hospital were selected as observation group,and 90 healthy persons who underwent physical examination were selected as control group.Serum LP-PLA2 and vascular endothelial indexes were compared between the two groups.At the same time,serum LP-PLA2 and vascular endothelial indexes,such as endothelin-1(ET-1),soluble vascular cell adhesion molecule-1(sVCAM-1),soluble intercellular adhesion molecules-1(sICAM-1)and von Willebrand factor(vWF),were compared between patients with different types and Gensini score in the observation group.The relationship between serum LP-PLA2 and Gensini score,vascular endothelial indexes were analyzed by Pearson correlation analysis.Results The serum LP-PLA2,ET-1,sVCAM-1,sICAM-1 and vWF were respectively(275.65±28.96)pg/mL,(28.98±5.12)ng/L,(223.63±25.68)g/L,(663.75±78.65)g/L and(120.35±18.96)U/L in the observation group,which were significantly higher than corresponding(122.32±18.96)pg/mL,(6.12±1.35)ng/L,(110.61±16.75)g/L,(320.17±28.96)g/L and(68.21±8.38)U/L in the control group(P<0.05).The serum LP-PLA2 and vascular endothelial indexes of patients with different types and Gensini scores in the observation group were all statistically significant(P<0.05).Pearson correlation analysis showed that serum LP-PLA2 was positively correlated with Gensini score and vascular endothelial indexes(r=0.756,0.812,0.903,0.887,and 0.796,respectively;all P<0.05).Conclusion Serum LP-PLA2 is closely related to the degree of coronary artery disease and vascular endothelial indexes in patients with coronary heart disease and has a high detection value in patients with coronary heart disease.