摘要
Dear Editor,The Ras superfamily of GTPases are conserved in eukary?otes from yeast to humans,and play essential roles in the regulation of a variety of key cellular processes,including cell differentiation and proliferation,membrane trafficking,nuclear import and export,cytoskeletal remodeling and mitogenic signaling(Karnoub and Weinberg,2008).Notably,numerous studies have shown that many members of the Ras-related small GTPases are involved in diverse aspects of tumorigenesis and tumor progress!on(Chen et al.,2014;Liu et al.,2017).
