摘要
The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu(I)/CPA cooperative catalysis has been developed.This method features the use of hydrosilane as the reductive radical precursor,enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine,indoline and isoindoline bearing anα-tertiary stereocenter with high enantioselectivity.The key to the success includes the use of Cu(I)/CPA cooperative catalyst system and theβ-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.
The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu(I)/CPA cooperative catalysis has been developed. This method features the use of hydrosilane as the reductive radical precursor, enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine, indoline and isoindoline bearing an α-tertiary stereocenter with high enantioselectivity. The key to the success includes the use of Cu(I)/CPA cooperative catalyst system and the β-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.
基金
supported by the National Natural Science Foundation of China(21722203,21831002,21801116,21572096)
Shenzhen Special Funds for the Development of Biomedicine,Internet,New Energy,and New Material Industries(JCYJ20170412152435366,JCYJ20170307105638498,JCYJ20180302180235837)
Guangdong Natural Science Foundation(2018A030310083)
Shenzhen Nobel Prize Scientists Laboratory Project(C17783101)
