脓毒症相关性脑病的研究进展

Research progress of sepsis-associated encephalopathy

脓毒症相关性脑病(sepsis associated encephalopathy,SAE),是脓毒症常见的一种并发症,是全身炎症反应引起的弥漫性的脑功能障碍状态,是重症监护病房(Intensive care unit,ICU)病死率增加的重要原因之一。临床主要表现为精神状态、意识的急性改变,又称脓毒症性脑病(septic encephalopathy,SE),最早于1827年由Bright提出,表明早期脓毒症患者的急性认知改变会增加患者的死亡率。

sepsis-associated encephalopathy is one of the common complication of sepsis,it’s a lack of evidence of the central nervous system infection.Diffuse brain dysfunction caused by systemic inflammatory response can increase the mortality rate of hospitalized patients and prolong hospital stay.It can also leave cognitive,memory and learning disabilities for a long time.Therefore,in-depth study of sepsis-associated encephalopathy is of great significance in improving the prognosis of patients with sepsis.In this paper,the epidemiological characteristics,pathogenesis,diagnosis and treatment of the disease are made a briefly stated.