高压氧对缺氧缺血性脑病新生儿血清sICAM-1及S100 B蛋白表达的影响

Effects of hyperbaric oxygen on serum sICAM-1 and S100B proteins in neonatal hypoxic ischemic encephalopathy

目的探讨高压氧(HBO)对缺氧缺血性脑病(HIE)新生儿血清sICAM-1、S100B蛋白表达的影响.方法选择郑州煤炭工业集团有限责任公司总医院2016年5月至2019年1月收治的62例HIE新生儿为研究对象,根据数字表法随机分为观察组和对照组,每组31例.对照组予常规治疗,观察组在对照组基础上予以HBO治疗.治疗10 d后,比较2组患者神经行为测定(NBNA)分值、神经反射与意识恢复时间、血清细胞间黏附分子1(sICAM-1)、S100B蛋白表达水平以及不良反应情况.结果治疗10 d后,2组患者NBNA评分均较治疗前明显提高,且观察组治疗后NBNA评分[(30.18±5.04)分]明显高于对照组[(24.59±5.14)分],差异均有统计学意义(P<0.05);观察组神经反射与意识恢复时间[(3.88±1.23)、(2.45±0.94)d]均明显短于对照组[(5.69±1.37)、(4.17±1.13)d],差异均有统计学意义(P<0.05);2组患者sICAM-1和S100B表达水平均较治疗前明显降低,且观察组治疗后明显低于对照组,差异均有统计学意义(P<0.05);治疗期间,观察组不良反应总发生率(12.9%)高于对照组(9.7%),但差异无统计学意义(P>0.05).结论HBO可提高HIE新生儿治疗效果,降低血清sICAM-1、S100B蛋白表达水平.

Objective To investigate the effects of hyperbaric oxygen(HBO)on serum intercellular adhesion molecule 1(sICAM-1)and S100B proteins in the newborns with hypoxic ischemic encephalopathy(HIE).Methods Sixty-two HIE newborns admitted to the hospital from May 2016 to January 2019 were selected as research subjects.According to the random cluster method,they were divided into the observation group and the control group,each consisting of 31 patients.The control group was given routine treatment,while the observation group received HBO in addition to the treatment received by the control group.Ten days after treatment,the levels of NBNA,nerve reflex and consciousness recovery time,sICAM-1,S100B protein expression and adverse reactions were compared between the patients of the 2 groups.Results Ten days after treatment,the NBNA scores of the 2 groups were all significantly higher than those before treatment.The NBNA scores of the observation group(30.18±5.04)was obviously higher than those of the control group(24.59±5.14),with statistical significance(P<0.05).Nerve reflex and consciousness recovery time of the observation group[(3.88±1.23),(2.45±0.94)d]were all significantly shorter than those of the control group[(5.69±1.37),(4.17±1.13)d],also with statistical significance(P<0.05).The expression levels of sICAM-1 and S100B in the patients of the 2 groups all decreased obviously as compared with those before treatment,and the levels of the observation group after treatment were evidently shorter than those of the control group,also with statistical significance(P<0.05).During the course of treatment,total rate of adverse reactions in the observation group was higher(12.9%)than that of the control group(9.7%),but without statistical significance(P>0.05).Conclusion HBO could improve the therapeutic effects on neonatal hypoxic ischemic encephalopathy and decrease the expression levels of SICAM-1 and S100B proteins.