核素显像在原发性醛固酮增多症患者中的应用

Application of radionuclide imaging in patients with primary aldosteronism

原发性醛固酮增多症(PA)是指体内无法抑制的醛固酮高分泌,导致肾素-血管紧张素系统被激活从而引起机体一系列病理生理改变的临床综合征。PA分为单侧和双侧肾上腺醛固酮分泌过多,两者的治疗方式存在本质差异,前者多采用手术治疗,而后者多采用药物治疗,如何早期分型对下一步的治疗具有重要的临床意义。核素显像包括正电子发射断层显像术(PET)与单光子发射断层显像术(SPECT),它们以分子探针、功能显像及无创性等为特征,在PA患者的分型诊断中发挥着越来越重要的作用。笔者就核素显像在PA中的研究进展进行综述。

Primary aldosteronism(PA)is a clinical syndrome in which excess production of the hormone aldosterone from the adrenal glands,leads to activation of the renin-angiotensin system,causing a series of pathophysiological changes in the body.PA is divided into unilateral or bilateral adrenal aldosterone secretion,and their treatment methods are essentially different.The former is mostly treated by operation,while the latter is mainly treated with drugs.It's very important to early identify the type of PA in clinical implication.Radionuclide imaging including positron emission tomography(PET)and single photon emission computed tomography(SPECT),which are characterized by molecular probes,functional imaging,and non-invasiveness,are playing an increasingly important role in the classification of PA patients.The author reviews the research progress of radionuclide imaging in PA.