多种PET/CT显像剂在食管癌放化疗疗效评价中的应用进展

Review on multiple PET/CT imaging agents in treatment response evaluation for esophageal cancer

放疗和化疗是治疗食管癌的重要手段,治疗后疗效评价对于制定个体化治疗方案具有重要意义。既往用于评价疗效的影像学技术仅基于形态学的变化,不能早期准确地反应肿瘤大小的变化,存在一定的局限性,而分子影像学技术PET/CT能够使用不同类型的显像剂,分别从代谢、增殖、乏氧、凋亡等方面早期评价治疗后反应,提高了诊断的灵敏度和特异度,具有较好的发展前景。笔者就多种PET/CT显像剂在食管癌非手术治疗疗效评价中的应用进展进行综述。

Radiotherapy and chemotherapy are important methods in the treatment of esophageal cancer.The evaluation of response after treatment has considerable importance for individualized treatment.The conventional imaging technology used to evaluate the response after therapy is only based on morphological changes,which cannot accurately reflect the early changes in tumor size.By contrast,the molecular imaging technology,PET/CT,can use different types of imaging agents to evaluate treatment response in terms of metabolism,proliferation,hypoxia,and apoptosis,which improves the diagnosis'sensitivity and specificity.Therefore,molecular imaging using multiple PET tracers is a promising new method for the evaluation of therapy response in esophageal cancer.The article reviews the PET/CT imaging agents used to examine the non-operation treatment response of esophageal cancer in recent years.