内源性硫化氢在百草枯中毒患者中的变化及意义

Changes and significance of endogenous hydrogen sulfide in patients with paraquat poisoning

目的探讨内源性硫化氢(H2S)在百草枯(PQ)中毒患者中的变化及意义。方法PQ中毒患者(29例),自入院后随访30d,记录死亡病例,分为中毒死亡组(17例)、中毒生存组(12例);对照组为门诊健康体检者(20例)。所有研究对象在入院24h内取静脉血,检测C反应蛋白、血常规WBC计数;取血清测定H2S浓度。记录各组患者年龄、性别,PQ中毒组患者服PQ的剂量。结果PQ中毒患者和对照组比较,年龄、性别无显著差别(P均>0.05);PQ中毒患者与对照组比较,H2S明显降低、CRP增高、WBC增高,差异均有统计学意义(P均<0.05);与中毒生存组比较,死亡组H2S显著降低、WBC显著增高、服毒量明显高于生存组(P均<0.05),死亡组患者年龄均值、男性比例高于生存组患者,但差异不显著(P均>0.05);血清H2S浓度与预后显著正相关(P<0.01),WBC、服毒量与预后呈负相关(P均<0.05)。结论PQ中毒患者血清H2S降低,H2S对PQ中毒患者的预后判断具有重要作用。

Objective To investigate the changes and significance of endogenous hydrogen sulfide(H 2S)in patients with paraquat(PQ)poisoning.Methods 29 patients with PQ poisoning were followed up for 30 days after admission.The patients were divided into poisoning death group(17 cases)and poisoning survival group(12 cases).The control group was a healthy physical examination in outpatient department(20 cases).Venous blood was taken within 24 hours after admission,C-reactive protein was measured and blood routine WBC count was measured.Venous blood was taken within 24 hours after admission,C-reactive protein was measured,blood routine WBC count,and serum H2S concentration was measured.The age,sex and dose of PQ in PQ poisoning group were recorded.Results There was no significant difference in age and sex among the patients with PQ poisoning and the control group(P>0.05).Compared with the control group,H2S decreased significantly,CRP increased and WBC increased significantly(P<0.05).Compared with the survival group,the concentration of H2S in the death group was significantly lower than that in the survival group,and the dose of H2S in the death group was significantly higher than that in the survival group(P<0.05).The mean age of the patients in the death group was higher than that in the survival group,but the difference was not significant(P>0.05),and there was a significant positive correlation between the concentration of serum H2S and the prognosis(P<0.05).Conclusion The decrease of serum H2S in patients with PQ poisoning plays an important role in predicting the prognosis of patients with PQ poisoning.