围绝经期及绝经后女性性激素水平与阻塞性睡眠呼吸暂停综合征相关性分析

Correlation between sex hormone levels and obstructive sleep apnea syndrome in perimenopausal or postmenopausal women

目的探讨围绝经期和绝经后女性性激素水平与发生阻塞性睡眠呼吸暂停综合征(OSAHS)之间的关系。方法选取2016年1月至2017年1月在复旦大学附属中山医院呼吸科睡眠呼吸障碍与鼾症诊治中心行睡眠监测的围绝经期和绝经后女性病人42例,经睡眠监护仪(PSG)监测分为正常组和异常组,分别检测2组病人体内性激素水平。结果正常组的呼吸暂停低通气指数(AHI)、觉醒指数、睡眠质量、最低血氧饱和度、平均血氧饱和度均显著优于异常组(P<0.05);OSAHS病人血清孕酮(P)、雌二醇(E2)水平与AHI呈负相关(r=-0.513,P=0.010;r=-0.426,P=0.031),与最低血氧饱和度呈正相关(r=0.449,P=0.027;r=0.517,P=0.023);E2水平与觉醒指数呈负相关(r=-0.446,P=0.029),和其他睡眠监测指标之间无显著相关性(P>0.05)。结论围绝经期及绝经后女性OSAHS的发生与体内雌激素、P水平下降具有相关性。

Objective To investigate the relationship between sex hormone levels and obstructive sleep apnea syndrome(OSAHS) in the perimenopausal or postmenopausal women.Methods Fortytwo perimenopausal or postmenopausal women in the Sleep Respiratory Disorder and Snoring Diagnosis and Treatment Center of Zhongshan Hospital Affiliated to Fudan University from January 2016 to January2017 were enrolled in this study.They were divided into normal group and abnormal group according to PSG monitoring results,and the levels of sex hormones were detected respectively.Results The apneahypopnea index(AHI),awakening index were significantly lower,and sleep quality,minimum oxygen saturation and average oxygen saturation were significantly higher in normal groups than those in abnormal groups(P< 0.05).There were negative correlations of serum progesterone(P) level and estradiol(E2) level with AHI in the patients with OSAHS(r=-0.513,P = 0.010;r=-0.426,P =0.031),and were positively correlated with lowest oxygen saturation(r = 0.449,P = 0.027;r = 0.517,P = 0.023).E2 level was negatively correlated with the awakening index(r =-0.446,P = 0.029),and had no significant correlation with other sleep monitoring indicators(P> 0.05).Conclusions The incidence of OSAHS in perimenopausal or postmenopausal women is correlated with the decrease of E2 and P levels.