血清Ghrelin、IGF-1水平在矮小症儿童诊断中的作用分析

Analysis on the Role of Serum Ghrelin and IGF-1 Levels in the Diagnosis of Children with Short Stature

目的分析血清Ghrelin、胰岛素样生长因子-1 (IGF-1)水平在矮小症儿童诊断中的作用。方法选取2015年1月至2017年12月期间我院收治的52名矮小症儿童作为研究组,同期身高正常的52名儿童作为参照组,比较两组的相关临床指标以及血清Ghrelin、IGF-1水平。结果研究组的身高、骨龄、甲状腺激素水平、生长速率均显著低于参照组,差异具有统计学意义(P<0.05)。研究组的血清Ghrelin水平显著高于参照组,血清IGF-1水平显著低于参照组,差异具有统计学意义(P<0.05)。结论在矮小症儿童的诊断中,血清IGF-1、Ghrelin水平可有效反映患儿机体内生长激素的分泌情况,对矮小症患儿的诊断具有重要的参考价值。

Objective To analyze the role of serum Ghrelin and insulin-like growth factors-1(IGF-1) levels in the diagnosis of children with short stature. Methods A total of 52 children with short stature admitted to our hospital from January 2015 to December 2017 were selected as the study group, and 52 children with normal body height at the same period were selected as the reference group. The related clinical indicators, and the serum levels of Ghrelin and IGF-1 of two groups were compared. Results The body height, bone age,thyroid hormone level and growth rate of the study group were significantly lower than those of the reference group, with statistical differences(P<0.05). The serum Ghrelin level of the study group was significantly higher than that of the reference group, and the serum IGF-1 level was significantly lower than that of the reference group, with statistical differences(P<0.05). Conclusions In the diagnosis of children with short stature, the levels of serum IGF-1 and Ghrelin can effectively reflect the secretion of growth hormone in the body of children, which have important reference value for the diagnosis of children with short stature.