DSA引导背根神经节脉冲射频治疗颈段带状疱疹后神经痛的临床观察

Clinical Observation of DSA-guided Dorsal Root Ganglion Pulsed Radiofrequency in the Treatment of Cervical Postherpetic Neuralgia

目的:探讨DSA引导背根神经节脉冲射频(PRF)用于颈段带状疱疹后神经痛(PHN)的临床效果。方法:选取2016年1月-2018年6月在本科住院治疗的颈段PHN患者66例,随机分为基础药物治疗组(对照组)和联合射频热凝组(研究组),每组各33例。对照组给予盐酸曲马朵缓释片、普瑞巴林等药物治疗,研究组在对照组药物治疗的基础上联合DSA引导下PRF治疗,观察两组治疗后1 d、1周、1个月、6个月疼痛缓解、睡眠及生活质量改善等情况。结果:研究组治疗后1 d、1周、1个月、6个月平均VAS、PSQI评分均显著低于对照组(P<0.05),IL-1β水平显著低于对照组(P<0.05)。研究组头晕、嗜睡、共济失调等不良反应发生率均显著低于对照组(P<0.05),治疗后SF-36量表总评分显著高于对照组(P<0.05)。结论:DSA引导下PRF应用于颈段PHN患者,疼痛缓解明显,炎性指标、睡眠、生活质量均改善明显,且不良反应较少。

Objective:To evaluate the clinical effect of DSA-guided dorsal root ganglion pulsed radiofrequency(PRF)in the treatment of cervical postherpetic neuralgia(PHN).Method:A total of 66 patients with cervical PHN admitted to our hospital from January 2016 to June 2018 were divided into two groups,33 cases in each group.The control group was given routine drug treatment,and the study group was treated with PRF guided by DSA,the pain relief,sleep and quality of life of two groups were observed.Result:On the 1st day,1st week,1st month and 6th month after treatment,the average VAS and PSQI scores in the study group were significantly lower than those in the control group(P<0.05),the levels of IL-1βin the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions such as dizziness,sleepiness and ataxia in the study group were significantly lower than those in the control group(P<0.05),the total score of SF-36 scale after treatment was significantly higher than that in the control group(P<0.05).Conclusion:DSA-guided PRF is used in the treatment of cervical PHN patients can achieve better pain relief and anti-inflammatory effect,is helpful to improve the total curative effect,sleep and quality of life,and has less adverse reactions.